-Valprolactone

Base Information

• Chemical Name: -Valprolactone
• CAS No.: 40923-58-8
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.198
• Hs Code.: 2932209090
• Mol file: 40923-58-8.mol

Synonyms:5-methyl-3-propyldihydrofuran-2(3H)-one;Pentanoic acid, 4-hydroxy-2-propyl, lactone;

Chemical Property of -Valprolactone

Chemical Property:

• Vapor Pressure: 0.0594mmHg at 25°C
• Refractive Index: 1.43
• Boiling Point: 232.3 °C at 760 mmHg
• Flash Point: 88.4 °C
• PSA: 26.30000
• Density: 0.945 g/cm³
• LogP: 1.73970
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

γ-Valprolactone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A metabolite of valproic acid A metabolite of valproic acid.

Technology Process of -Valprolactone

There total 10 articles about -Valprolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

dihydro-5-methyl-3-(2-propenyl)-2(3H)-furanone (3926-76-9) → 5-methyl-3-propyldihydrofuran-2(3H)-one (40923-58-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at -78 ℃; for 2h; under 2844.39 - 3102.97 Torr;

DOI:10.1021/ol503432b

Reference yield: 75.0%

ethyl 5-methyl-2-oxo-3-propyltetrahydrofuran-3-carboxylate (200126-81-4) → 5-methyl-3-propyldihydrofuran-2(3H)-one (40923-58-8)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 4.5h; Heating;

DOI:10.1134/S1070428008060122

Reference yield:

C10H17BrF3NO → 5-methyl-3-propyldihydrofuran-2(3H)-one (40923-58-8)

Guidance literature:

C₁₀H₁₇BrF₃NO; With silver tetrafluoroborate; In dichloromethane; at 20 ℃; for 0.5h; Darkness;

With water; In dichloromethane; at 20 ℃; for 15h; Darkness;

DOI:10.1021/acs.orglett.6b03371

upstream raw materials:

dihydro-5-methyl-3-(2-propenyl)-2(3H)-furanone

(+/-)-5-methyl-3-prop-2-ynyl-3H-furan-2-one

(+/-)-5-methyl-3-prop-2-ynyl-5H-furan-2-one

2,2-di(prop-2-ynyl)propan-1,3-dioic acid

Refernces

• 1、 Romanens, Alexandre,Blanger, Guillaume. "Preparation of conformationally restricted β2,2- and β2,2,3-amino esters and derivatives containing an all-carbon quaternary center". supporting information. p. 322 - 325. Retrieved 2015/01/30.
• 2、 Schaefer,Luehrs. "Metabolite pattern of valproic acid. I. Gaschromatographic determination of the valproic acid metabolite artifacts, heptanone-3, 4- and 5-hydroxyvalproic acid lactone". . p. 657 - 662,658,660. Retrieved 2007/10/05.