1-Thiazol-2-yl-ethanol

Base Information

• Chemical Name: 1-Thiazol-2-yl-ethanol
• CAS No.: 40982-30-7
• Molecular Formula: C5H7NOS
• Molecular Weight: 129.183
• Hs Code.: 2934100090
• European Community (EC) Number: 832-185-6
• Nikkaji Number: J3.177.313J
• Mol file: 40982-30-7.mol

Synonyms:1-Thiazol-2-yl-ethanol;40982-30-7;1-(1,3-thiazol-2-yl)ethanol;1-(thiazol-2-yl)ethan-1-ol;2-Thiazolemethanol, alpha-methyl- (7CI,9CI);1-(1,3-thiazol-2-yl)ethan-1-ol;1-(2-Thiazolyl)ethanol;SCHEMBL507980;YTYLXXDUJXUJJJ-UHFFFAOYSA-N;MFCD13184171;AKOS012296101;AT14680;AM100799;2-Thiazolemethanol,alpha-methyl-(7ci,9ci);CS-0179471;FT-0688692;EN300-67229;J-505157;Z1069884516

Chemical Property of 1-Thiazol-2-yl-ethanol

Chemical Property:

• Boiling Point: 200oC
• Flash Point: 75oC
• PSA: 61.36000
• Density: 1.251
• LogP: 1.19640
• Storage Temp.: 2-8°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 129.02483502
• Heavy Atom Count: 8
• Complexity: 78.8

Purity/Quality:

99.3% ^*data from raw suppliers

1-Thiazol-2-yl-ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=NC=CS1)O
• Uses: 1-Thiazol-2-yl-ethanol is used in preparation of sulfonylurea compounds for treating conditions associated with NLRP activity.

Technology Process of 1-Thiazol-2-yl-ethanol

There total 9 articles about 1-Thiazol-2-yl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Acetylthiazole (24295-03-2,260998-74-1) → (±)-1-(thiazol-2-yl)ethanol (40982-30-7,134932-60-8)

Guidance literature:

With zirconium dioxide hydrate; isopropyl alcohol; at 130 ℃; for 0.583333h;

DOI:10.1021/ol400856g

Reference yield: 85.0%

2-(trimethylsilyl)thiazole (79265-30-8) + acetaldehyde (75-07-0,9002-91-9) → (±)-1-(thiazol-2-yl)ethanol (40982-30-7,134932-60-8)

Guidance literature:

DOI:10.1021/jo952082t

Reference yield: 80.0%

3-Methyl-1,2,3-triazolo[5,1-b]thiazole (134271-26-4) → (±)-1-(thiazol-2-yl)ethanol (40982-30-7,134932-60-8)

Guidance literature:

With sulfuric acid; for 2.5h; Heating;

DOI:10.1016/S0040-4020(01)87090-3

upstream raw materials:

2-bromo-1,3-thiazole

acetaldehyde

3-Methyl-6-trimethylsilyltriazolothiazole

3-Methyl-1,2,3-triazolo[5,1-b]thiazole

Downstream raw materials:

2-Acetylthiazole

1-(2-Thyazolyl)aethylchlorid

(R)-1-(2-thiazolyl)ethanol

(S)-2-(1-hydroxyethyl)thiazole

Refernces

• 1、 -. "COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY". Page/Page column 448. . Retrieved 2019/02/13.
• 2、 Magata, Takuji,Hirokawa, Yoshimi,Furokawa, Aya,Takeuchi, Kazuhisa,Ohtomo, Yoshiaki,Kino, Toshitaka,Kominami, Jun,Nakai, Yuto,Kitamura, Maria,Maezaki, Naoyoshi. "Highly diastereoselective synthesis of 2-(1-N-Boc-aminoalkyl)thiazole-5-carboxylates by reduction of tert-butylsulfinyl ketimines". . p. 416 - 422. Retrieved 2018/04/09.