1,1,2,2-Tetrafluoro-1,2-bis(4-fluorophenyl)ethane

Base Information

• Chemical Name: 1,1,2,2-Tetrafluoro-1,2-bis(4-fluorophenyl)ethane
• CAS No.: 4100-99-6
• Molecular Formula: C14H8F6
• Molecular Weight: 290.208
• Hs Code.: 2903999090
• DSSTox Substance ID: DTXSID30457720
• Nikkaji Number: J2.645.269D
• Wikidata: Q82280678
• Mol file: 4100-99-6.mol

Synonyms:1,1,2,2-Tetrafluoro-1,2-bis(4-fluorophenyl)ethane;4100-99-6;1-fluoro-4-[1,1,2,2-tetrafluoro-2-(4-fluorophenyl)ethyl]benzene;1,1'-(1,1,2,2-Tetrafluoroethane-1,2-diyl)bis(4-fluorobenzene);1,2-Bis-(4-fluorophenyl)-1,1,2,2-tetrafluoroethane;1,2-BIS(4-FLUOROPHENYL)-1,1,2,2-TETRAFLUOROETHANE;SCHEMBL5388697;DTXSID30457720;MFCD01631642;AKOS015999002;A825388;1,2-bis-(4'-Fluorophenyl)-1,1,2,2-tetrafluoroethane;5-CHLORO-1-METHYL-1H-PYRAZOLE-4-CARBONYLCHLORIDE

Chemical Property of 1,1,2,2-Tetrafluoro-1,2-bis(4-fluorophenyl)ethane

Chemical Property:

• Melting Point: 96-97oC
• Boiling Point: 255.3oC at 760 mmHg
• Flash Point: 85.4oC
• PSA: 0.00000
• Density: 1.35g/cm3
• LogP: 4.84860
• Storage Temp.: 2-8°C
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 290.05301923
• Heavy Atom Count: 20
• Complexity: 282

Purity/Quality:

98.5% ^*data from raw suppliers

1,1,2,2-Tetrafluoro-1,2-bis(4-fluorophenyl)ethane 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(C(C2=CC=C(C=C2)F)(F)F)(F)F)F

Technology Process of 1,1,2,2-Tetrafluoro-1,2-bis(4-fluorophenyl)ethane

There total 7 articles about 1,1,2,2-Tetrafluoro-1,2-bis(4-fluorophenyl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1,2-bis(4-fluorophenyl)ethane-1,2-dione (579-39-5) → 1,2-bis(4-fluorophenyl)-1,1,2,2-tetrafluoroethane (4100-99-6)

Guidance literature:

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; at 90 ℃; for 24h;

DOI:10.1016/j.tet.2008.08.009

Reference yield: 80.0%

→ 1,2-bis(4-fluorophenyl)-1,1,2,2-tetrafluoroethane (4100-99-6)

Guidance literature:

Reference yield: 57.0%

2,2'-bis-(4-fluoro-phenyl)-[2,2']bi[[1,3]dithianyl] → 1,2-bis(4-fluorophenyl)-1,1,2,2-tetrafluoroethane (4100-99-6)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrogenfluoride; In dichloromethane; at -78 - 20 ℃; for 18h;

DOI:10.1016/j.jfluchem.2004.01.016

upstream raw materials:

α,α,α',α'-tetrachloro-4,4'-difluoro-bibenzyl

4-fluoro-1-trichloromethylbenzene

1,2-bis(4-fluorophenyl)ethane-1,2-dione

Downstream raw materials:

1,1,2,2-Tetrafluor-1,2-bis-<3-amino-4-fluor-phenyl>-aethan

1,1,2,2-Tetrafluor-1,2-bis-<4-fluor-3-nitro-phenyl>-aethan

1,2-bis[4-(2-hydroxyethoxy)phenyl]-1,1,2,2-tetrafluoroethane

1,2-di(4-benzyloxyphenyl)tetrafluoroethane

Refernces

• 1、 Chang, Ying,Tewari, Amit,Adi, Avi-Izak,Bae, Chulsung. "Direct nucleophilic fluorination of carbonyl groups of benzophenones and benzils with Deoxofluor". . p. 9837 - 9842. Retrieved 2008/12/22.
• 2、 -. "Fluorine-containing bisphenols, their preparation, their precursors and intermediates, and use of the fluorine-containing bisphenols". . . Retrieved 2008/06/13.