Cyclooctanecarboxylic acid

Base Information

• Chemical Name: Cyclooctanecarboxylic acid
• CAS No.: 4103-15-5
• Molecular Formula: C9H16O2
• Molecular Weight: 156.225
• Hs Code.: 2916209090
• Mol file: 4103-15-5.mol

Synonyms:Cyclooctancarbonsaeure;Cyclooctylcarbonsaeure;cyclooctanoic acid;cyclo-octancarboxylic acid;cyclooctyl carboxylic acid;

Chemical Property of Cyclooctanecarboxylic acid

Chemical Property:

• PSA: 37.30000
• LogP: 2.43150

Purity/Quality:

95% ^*data from raw suppliers

CyclooctanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclooctanecarboxylic acid

There total 6 articles about Cyclooctanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

carbon monoxide (201230-82-2) + cyclooctyl chloride (1556-08-7) + sodium tert-pentoxide (14593-46-5) → cyclooctylcarboxaldehyde (6688-11-5) + cyclooctanecarboxylic acid (4103-15-5) + Cyclooctanecarboxylic acid 1,1-dimethyl-propyl ester

Guidance literature:

With iron(III) chloride; sodium hydride; In 1,2-dimethoxyethane; at 65 ℃; for 14h; Product distribution; C₈H₁₅Cl/FeCl₃=10, C₈₅H₁₅Cl/NaH/Am-t-ONa/FeCl₃=10/40/20/1 mmol;

DOI:10.1021/jo00328a039

Reference yield: 14.2%

Cyclooctan (292-64-8) + carbon monoxide (201230-82-2) → cycloactanone (502-49-8) + cyclooctanol (696-71-9) + cyclooctanecarboxylic acid (4103-15-5)

Guidance literature:

With dipotassium peroxodisulfate; 4C₈H₇O₃^(1-)*3Cu⁽²⁺⁾*2H₂O*2HO^(1-); In water; acetonitrile; at 60 ℃; for 4h; under 15201 Torr; Reagent/catalyst; Catalytic behavior; Autoclave;

DOI:10.1021/acs.inorgchem.1c01268

Reference yield: 13.4%

Cyclooctan (292-64-8) + carbon monoxide (201230-82-2) → cycloactanone (502-49-8) + cyclooctanecarboxylic acid (4103-15-5)

Guidance literature:

With dipotassium peroxodisulfate; C₃₆H₅₀Cu₂N₄O₄⁽²⁺⁾*2NO₃^(1-); In water; acetonitrile; at 60 ℃; for 4h; under 15201 Torr; Reagent/catalyst; Overall yield = 22 %; Autoclave;

DOI:10.1016/j.molcata.2016.07.050

upstream raw materials:

cyclooctylmethanol

carbon monoxide

cyclooctyl chloride

sodium tert-pentoxide

Downstream raw materials:

cyclooctanecarbonyl chloride

tert.-Butyl-cyclooctanperoxycarboxylat

2-(1-Isocyanato-cyclooctylmethyl)-benzoic acid isopropyl ester

Cyclooctan

Refernces

• 1、 Trusau, Kiryl I.,Kirillova, Marina V.,André, Vania,Usevich, Andrew I.,Kirillov, Alexander M.. "Mild oxidative functionalization of cycloalkanes catalyzed by novel dicopper(II) cores". . . Retrieved 2021/02/09.
• 2、 Armakola, Eirini,Colodrero, Rosario M. P.,Bazaga-García, Montse,Salcedo, Inés R.,Choquesillo-Lazarte, Duane,Cabeza, Aurelio,Kirillova, Marina V.,Kirillov, Alexander M.,Demadis, Konstantinos D.. "Three-Component Copper-Phosphonate-Auxiliary Ligand Systems: Proton Conductors and Efficient Catalysts in Mild Oxidative Functionalization of Cycloalkanes". . p. 10656 - 10666. Retrieved 2018/09/13.