6-CHLORO-4'-METHYLFLAVONE

Base Information

• Chemical Name: 6-CHLORO-4'-METHYLFLAVONE
• CAS No.: 41255-31-6
• Molecular Formula: C16H11ClO2
• Molecular Weight: 270.715
• Mol file: 41255-31-6.mol

Synonyms:6-chloro-2-p-tolyl-chromen-4-one;CCG-8749;6-chloro-2-phenyl-4H-chromen-4-one;6-CHLORO-4'-METHYLFLAVONE;F3139-0626;6-chloro-2-p-tolyl-4H-chromen-4-one;7-methoxy-2-p-tolyl-4H-chromen-4-one;

Chemical Property of 6-CHLORO-4'-METHYLFLAVONE

Chemical Property:

• PSA: 30.21000
• LogP: 4.42180

Purity/Quality:

98.5% ^*data from raw suppliers

6-CHLORO-4'-METHYLFLAVONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-4'-METHYLFLAVONE

There total 14 articles about 6-CHLORO-4'-METHYLFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-chloro-4'-methylflavanone (131168-60-0,26029-22-1) → 6-chloro-2-(p-tolyl)-4H-chromen-4-one (41255-31-6)

Guidance literature:

With thallium(III) acetate; In acetic acid; for 3h; Heating;

Reference yield: 92.0%

1-(5-Chloro-2-hydroxy-phenyl)-3-p-tolyl-propane-1,3-dione → 6-chloro-2-(p-tolyl)-4H-chromen-4-one (41255-31-6)

Guidance literature:

With gallium(III) triflate; In nitromethane; at 80 ℃; for 2h;

DOI:10.3184/030823409X396409

Reference yield: 91.0%

C16H12BrClO2 (1301225-13-7) → 6-chloro-2-(p-tolyl)-4H-chromen-4-one (41255-31-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h; under air;

DOI:10.1002/anie.201007302

upstream raw materials:

6-chloro-4'-methylflavanone

2-acetyl-4-chlorophenyl 4-methylbenzoate

C₁₆H₁₂BrClO₂

C₁₇H₁₅ClO₃

Refernces

• 1、 Lee, Jae In,Kim, Han Nah. "Synthesis of Flavones by Thallium(III) p-tosylate-catalyzed Regioselective Cyclization of o-(Alkynon-1-yl)phenols". . p. 1113 - 1116. Retrieved 2018/09/19.
• 2、 Banerjee, Dipanwita,Kayal, Utpal,Maiti, Gourhari. "An efficient oxidative conversion of 2-aryl-2H-chromenes to the corresponding flavones by tert-butylhydroperoxide and copper bromide". . p. 1667 - 1671. Retrieved 2016/04/04.