Di(p-tolyl)phosphinoyl chloride

Base Information

• Chemical Name: Di(p-tolyl)phosphinoyl chloride
• CAS No.: 4129-40-2
• Molecular Formula: C14H14ClOP
• Molecular Weight: 264.691
• Hs Code.: 2903999090
• Mol file: 4129-40-2.mol

Synonyms:

Chemical Property of Di(p-tolyl)phosphinoyl chloride

Chemical Property:

• PSA: 26.88000
• LogP: 3.77110

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Di(p-tolyl)phosphinoyl chloride

There total 8 articles about Di(p-tolyl)phosphinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di(p-tolyl)phosphine oxide (2409-61-2) → di(p-tolyl)phosphinic chloride (4129-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dihydrogen peroxide; sodium hydroxide / 1 h / 100 °C / Inert atmosphere

2: thionyl chloride / toluene / 3 h / 80 °C / Inert atmosphere

With thionyl chloride; dihydrogen peroxide; sodium hydroxide; In toluene;

DOI:10.1002/anie.201606637

Reference yield:

bis(4-methylphenyl)phosphinic acid (1084-11-3) → di(p-tolyl)phosphinic chloride (4129-40-2)

Guidance literature:

With thionyl chloride; for 2h; Heating;

DOI:10.1016/0040-4020(82)80240-8

Reference yield:

chlorodi-p-tolylphosphane (1019-71-2) → di(p-tolyl)phosphinic chloride (4129-40-2)

Guidance literature:

With oxygen; In benzene; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja9041127

upstream raw materials:

bis(4-methylphenyl)phosphinic acid

para-methylphenylmagnesium bromide

chlorodi-p-tolylphosphane

para-bromotoluene

Downstream raw materials:

2,2'-bis(di-p-tolylphosphino)-1,1'-binaphthyl dioxide

di(4-tolyl)phosphinic acid 4-nitrophenyl ester

Di-p-tolyl-phosphinic acid p-tolyl ester

Refernces

• 1、 De Abreu, Maxime,Belmont, Philippe,Brachet, Etienne. "Light-Enabled Radical 1,4-Aryl Migration Via a Phospho-Smiles Rearrangement". . p. 3758 - 3767. Retrieved 2021/02/01.
• 2、 Wang, Jing,Deng, Guogang,Liu, Chunxiang,Chen, Zhuo,Yu, Kaili,Chen, Wen,Zhang, Hongbin,Yang, Xiaodong. "Transition Metal-Free Synthesis of α-Aminophosphine Oxides through C(sp3)?P Coupling of 2-Azaallyls". supporting information. p. 2268 - 2273. Retrieved 2020/03/04.