3-Phenyl-2-chloro-3-oxopropionic acid ethyl ester

Base Information

• Chemical Name: 3-Phenyl-2-chloro-3-oxopropionic acid ethyl ester
• CAS No.: 41381-97-9
• Molecular Formula: C₁₁H₁₁ClO₃
• Molecular Weight: 226.66
• Mol file: 41381-97-9.mol

Synonyms:

Chemical Property of 3-Phenyl-2-chloro-3-oxopropionic acid ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-CHLORO-3-PHENYL-PROPIONIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Phenyl-2-chloro-3-oxopropionic acid ethyl ester

There total 9 articles about 3-Phenyl-2-chloro-3-oxopropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) → ethyl 2-chloro-3-oxo-3-phenylpropionate (41381-97-9,146368-56-1)

Guidance literature:

With sulfuryl dichloride;

DOI:10.1021/jo0516077

Reference yield: 92.0%

N-chloro-succinimide (128-09-6) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → ethyl 2-chloro-3-oxo-3-phenylpropionate (41381-97-9,146368-56-1)

Guidance literature:

amberlyst-15; In ethyl acetate; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2004.11.140

Reference yield: 84.0%

→ ethyl 2-chloro-3-oxo-3-phenylpropionate (41381-97-9,146368-56-1)

Guidance literature:

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

sulfuryl dichloride

N-chloro-succinimide

acetophenone

Downstream raw materials:

2-(N'-acetyl-hydrazino)-4-phenyl-thiazole-5-carboxylic acid ethyl ester

4-phenyl-2-(4-sulfamoyl-phenyl)-thiazole-5-carboxylic acid ethyl ester

ethyl 5-methyl-3-phenyl-1-benzofuran-2-carboxylate

4,4'-diphenyl-[2,2']bithiazolyl-5,5'-dicarboxylic acid diethyl ester

Refernces

• 1、 Yu, Dan,Ji, Ruixue,Sun, Zhihui,Li, Wenjie,Liu, Zhong-Quan. "Electrochemical chlorination and bromination of electron-deficient C[sbnd]H bonds in quinones, coumarins, quinoxalines and 1,3-diketones". supporting information. . Retrieved 2021/11/16.
• 2、 Bie, Songtao,Li, Fangyi,Li, Zheng,Qiu, Changfu,Qiu, Chuanjiang,Suo, Tongchuan,Wang, Chunhua,Yu, Heshui. "Metal-Free Halogenation of N-Substituted Enaminoesters and Enaminones: A Facile Access to Functionalized α,α-Dihaloimines". . p. 1301 - 1314. Retrieved 2020/04/15.