3,4,5-TRIMETHOXYBENZO-AMIDITE HYDROCLORIDE

Base Information

• Chemical Name: 3,4,5-TRIMETHOXYBENZO-AMIDITE HYDROCLORIDE
• CAS No.: 4156-59-6
• Molecular Formula: C10H14N2O3.ClH
• Molecular Weight: 246.69100
• Mol file: 4156-59-6.mol

Synonyms:3,4,5-trimethoxybenzene-1-carboximidamide hydrochloride;3,4,5-Trimethoxybenzimidamide hydrochloride;

Chemical Property of 3,4,5-TRIMETHOXYBENZO-AMIDITE HYDROCLORIDE

Chemical Property:

• PSA: 77.56000
• LogP: 2.59850

Purity/Quality:

97% ^*data from raw suppliers

3,4,5-Trimethoxybenzimidamidehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4,5-TRIMETHOXYBENZO-AMIDITE HYDROCLORIDE

There total 3 articles about 3,4,5-TRIMETHOXYBENZO-AMIDITE HYDROCLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 3,4,5-trimethoxybenzenecarboximidate hydrochloride → 3,4,5-trimethoxybenzenecarboximidamide hydrochloride (4156-59-6)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 48h;

DOI:10.1002/hlca.200390137

Reference yield: 78.0%

3,4,5-trimethoxybenziminoethylether hydrochloride (4156-61-0) → 3,4,5-trimethoxy benzenecarboximidamide hydrochloride (4156-59-6)

Guidance literature:

With ammonia; In methanol; ethanol; at 20 ℃; for 24h; Sealed tube;

DOI:10.1016/j.tet.2014.01.019

Reference yield:

3,4,5-trimethoxybenzonitrile (1885-35-4) → 3,4,5-trimethoxybenzenecarboximidamide hydrochloride (4156-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / HCl (g) / 48 h / 20 °C

2: 85 percent / NH₃ / methanol / 48 h / 20 °C

With hydrogenchloride; ammonia; In methanol;

DOI:10.1002/hlca.200390137

upstream raw materials:

3,4,5-trimethoxybenziminoethylether hydrochloride

3,4,5-trimethoxybenzonitrile

Downstream raw materials:

3,5-bis(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole

Refernces

• 1、 Schmitt, Jean-Louis,Stadler, Adrian-Mihail,Kyritsakas, Nathalie,Lehn, Jean-Marie. "Helicity-encoded molecular strands: Efficient access by the hydrazone route and structural features". . p. 1598 - 1624. Retrieved 2007/10/03.