2-Hydroxyquinoline-4-carbohydrazide

Base Information

• Chemical Name: 2-Hydroxyquinoline-4-carbohydrazide
• CAS No.: 41874-24-2
• Molecular Formula: C10H9N3O2
• Molecular Weight: 203.2
• Mol file: 41874-24-2.mol

Synonyms:2-Oxo-1,2-dihydro-quinoline-4-carboxylic acid hydrazide;2-Oxo-1,2-dihydro-4-chinolincarbohydrazid;

Chemical Property of 2-Hydroxyquinoline-4-carbohydrazide

Chemical Property:

• Melting Point: 290 - 291 °C (ethanol)
• PSA: 87.98000
• LogP: 1.22280

Purity/Quality:

98%min ^*data from raw suppliers

2-Hydroxyquinoline-4-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hydroxyquinoline-4-carbohydrazide

There total 6 articles about 2-Hydroxyquinoline-4-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

methyl 1,2-dihydro-2-oxoquinoline-4-carboxylate (39497-01-3) → 2-oxo-1,2-dihydroquinoline-4-carbohydrazide (41874-24-2)

Guidance literature:

With hydrazine hydrate; In methanol; at 85 ℃; for 6h;

DOI:10.1016/j.molstruc.2019.06.053

Reference yield: 68.0%

ethyl 2-oxo-1,2-dihydroquinoline-4-carboxylate → 2-oxo-1,2-dihydroquinoline-4-carbohydrazide (41874-24-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 85 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.05.096

Reference yield:

2-quinolone-4-carboxylic acid (15733-89-8) → 2-oxo-1,2-dihydroquinoline-4-carbohydrazide (41874-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetyl chloride / 12 h / Inert atmosphere; Reflux

2: hydrazine hydrate / ethanol / 85 °C / Inert atmosphere

With hydrazine hydrate; acetyl chloride; In ethanol;

DOI:10.1016/j.bmcl.2012.05.096

upstream raw materials:

ethyl 2-hydroxyquinoline-4-carboxylate

2-quinolone-4-carboxylic acid

indole-2,3-dione

methyl 1,2-dihydro-2-oxoquinoline-4-carboxylate

Refernces

• 1、 Chawla, Har Mohindra,Gupta, Tanu. "Design, synthesis and evaluation of a new calix[4]arene based molecular receptor for multiple ion selectivity". . p. 49 - 56. Retrieved 2015/04/22.