Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, lithium salt

Base Information

• Chemical Name: Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, lithium salt
• CAS No.: 42031-71-0
• Molecular Formula: C15H24O.Li
• Molecular Weight: 226.288
• Mol file: 42031-71-0.mol

Synonyms:

Chemical Property of Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, lithium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, lithium salt

There total 2 articles about Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-, lithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,6-di-tert-butyl-4-methyl-phenol (128-37-0) → lithium 2,6-di-tert-butyl-4-methylphenoxide (42031-71-0)

Guidance literature:

With n-butyllithium; In diethyl ether; hexane; at 0 ℃; for 0.5h;

DOI:10.1021/ja00526a053

Reference yield:

1,3-di-tert-butyl-2-methoxy-5-methylbenzene (1518-53-2) → lithium 2,6-di-tert-butyl-4-methylphenoxide (42031-71-0)

Guidance literature:

With 4,4'-di-tert-butylbiphenyl; lithium;

DOI:10.1055/s-0029-1218797

Reference yield: 89.0%

Cp*TiCl3 (12129-06-5) + lithium 2,6-di-tert-butyl-4-methylphenoxide (42031-71-0) → (2,6-di-tert-butyl-4-methylphenyloxo)(pentamethylcyclopentadienyl)titanium(IV) dichloride (928791-08-6)

Guidance literature:

In toluene; under N2, in vac. drybox; org. ligand (1.0 equiv.) added in one portion to soln. of Ti complex (2.94 mmol) (room temp.); stirred (70°C, 10 h); filtered; filter cake washed with toluene; filtrate and wash combined; evapd. to dryness (vac.); solid dissolved in min. amt. of CH2Cl2; layeredby n-hexane (-25°C); elem. anal.;

DOI:10.1016/j.molcata.2006.03.030

upstream raw materials:

2,6-di-tert-butyl-4-methyl-phenol

1,3-di-tert-butyl-2-methoxy-5-methylbenzene

Downstream raw materials:

2',6'-di-tert-butyl-4'-methylphenyl (RS)-2-(benzyloxy)propanoate

N-<2,4,6-tri(tert-butyl)phenyl>phosphenimidous acid 2,6-di-tert-butyl-4-methylphenyl ester

C₂₀H₃₄Cl₂OP₂

2,6-di-tert-butyl-4-methylphenyl-(2SR,3RS,4SR,5RS,6SR)-2-O-benzyl-3,5-O-isopropylidene-2,3,5-trihydroxy-2,4,6,8-tetramethylnon-7-enoate

Refernces

• 1、 Knorr, Rudolf,Rossmann, Eva Christine,Knittl, Monika. "Easier preparation of 2,6-Di-tert-butylphenyl derivatives 1". scheme or table. p. 2124 - 2128. Retrieved 2010/09/04.