9-Phenylacridine

Base Information

• Chemical Name: 9-Phenylacridine
• CAS No.: 602-56-2
• Molecular Formula: C19H13N
• Molecular Weight: 255.319
• Hs Code.: 2933990090
• European Community (EC) Number: 210-020-3
• NSC Number: 62730
• DSSTox Substance ID: DTXSID00870669
• Nikkaji Number: J79.701D
• Wikidata: Q72501155
• ChEMBL ID: CHEMBL332209
• Mol file: 602-56-2.mol

Synonyms:9-phenyl acridine;9-phenylacridine

Chemical Property of 9-Phenylacridine

Chemical Property:

• Appearance/Colour: Yellow Powder
• Melting Point: 184°C
• Refractive Index: 1.6500 (estimate)
• Boiling Point: 411.1 °C at 760 mmHg
• PKA: 5.45±0.10(Predicted)
• Flash Point: 179.8 °C
• PSA: 12.89000
• Density: 1.181 g/cm³
• LogP: 5.05500
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 255.104799419
• Heavy Atom Count: 20
• Complexity: 298

Purity/Quality:

99% ^*data from raw suppliers

9-Phenylacridine >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C3C=CC=CC3=NC4=CC=CC=C42

Technology Process of 9-Phenylacridine

There total 116 articles about 9-Phenylacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

9-phenylacridinediazonium tetrafluoroborate → 9-phenylacridine (602-56-2)

Guidance literature:

With copper(I) oxide; hypophosphorous acid; In dichloromethane; water; acetonitrile; at 0 - 20 ℃;

DOI:10.1002/chem.200801863

Reference yield: 99.0%

9-Chloroacridine (1207-69-8) + phenylboronic acid (98-80-6) → 9-phenylacridine (602-56-2)

Guidance literature:

With potassium phosphate; In toluene; at 100 ℃; for 24h; Reagent/catalyst; Solvent; Time; Temperature; Catalytic behavior; Schlenk technique; Inert atmosphere;

DOI:10.1039/c7cc06958h

Reference yield: 95.0%

phenyl(2-(phenylamino)phenyl)methanone (23699-69-6) → 9-phenylacridine (602-56-2)

Guidance literature:

With t-butyl bromide; In 2,2,2-trifluoroethanol; at 20 ℃; for 24h; Solvent; Inert atmosphere;

DOI:10.1021/acs.joc.0c00137

upstream raw materials:

2-(phenylamino)benzoic acid

9-phenyl-9,10-dihydroacridine

N,N-diphenylbenzamidine

N,N-diphenylbenzamide

Downstream raw materials:

4-benzyl-9-phenyl-acridine

N-methyl-9-phenylacridinium iodide

9-phenyl-9,10-dihydroacridine

4-phenyl-3-quinolinecarboxylic acid

Refernces

• 1、 Gromachevskava, Elena V.,Kaigorogova, Elena A.,Bespalov, Alexander V.,Demidov, Oleg P.,Krapivin, Gennady D.. "Investigation in the field of quinazolines. 8*. New reaction of N-alkylation of 4,4-diphenyl-3,4-dihydroquinazolines". . . Retrieved 2020.
• 2、 Song, Di,Zhang, Nan,Zhang, Panpan,Zhang, Na,Chen, Weijin,Zhang, Long,Guo, Ting,Gu, Xiaotong,Ma, Shutao. "Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents". . . Retrieved 2021/05/10.
• 3、 Ye, Xuanzeng,Xu, Beihang,Sun, Jiani,Dai, Ling,Shao, Yinlin,Zhang, Yetong,Chen, Jiuxi. "Pd-Catalyzed Approach for Assembling 9-Arylacridines via a Cascade Tandem Reaction of 2-(Arylamino)benzonitrile with Arylboronic Acids in Water". . p. 13004 - 13014. Retrieved 2020/11/23.