3,5-BIS(TRIFLUOROMETHYL)PHENYLMETHYLSULFONE

Base Information

• Chemical Name: 3,5-BIS(TRIFLUOROMETHYL)PHENYLMETHYLSULFONE
• CAS No.: 4210-04-2
• Molecular Formula: C9H6F6O2S
• Molecular Weight: 292.202
• Mol file: 4210-04-2.mol

Synonyms:

Chemical Property of 3,5-BIS(TRIFLUOROMETHYL)PHENYLMETHYLSULFONE

Chemical Property:

• PSA: 42.52000
• LogP: 4.20850

Purity/Quality:

95% ^*data from raw suppliers

3,5-Bis(trifluoromethyl)phenylmethylsulfone 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-BIS(TRIFLUOROMETHYL)PHENYLMETHYLSULFONE

There total 5 articles about 3,5-BIS(TRIFLUOROMETHYL)PHENYLMETHYLSULFONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,5-bis(trifluoromethyl)thiophenol (130783-02-7) + methyl iodide (74-88-4) → 3,5-bis(trifluoromethyl)phenyl methyl sulfone (4210-04-2)

Guidance literature:

3,5-bis(trifluoromethyl)thiophenol; With sodium hydride;

methyl iodide;

With 3-chloro-benzenecarboperoxoic acid;

DOI:10.1021/acscatal.6b03434

Reference yield: 78.0%

C8H6F6N2O2S + Dimethyl phosphite (868-85-9) → 3,5-bis(trifluoromethyl)phenyl methyl sulfone (4210-04-2)

Guidance literature:

With sodium iodide; In 1,2-dimethoxyethane; water; at 65 ℃;

DOI:10.1055/a-1581-2271

Reference yield:

[3,5-bis(trifluoromethyl)phenyl] methyl sulfide (685892-24-4) → 3,5-bis(trifluoromethyl)phenyl methyl sulfone (4210-04-2)

Guidance literature:

With manganese(II) sulfate; NaHCO₃ buffer; dihydrogen peroxide; In acetonitrile; at 20 ℃;

DOI:10.1021/jo050852n

upstream raw materials:

Monothiophosphorsaeure-O,O-dimethylester-S-<3,5-bis-(trifluormethyl)-phenylester>

[3,5-bis(trifluoromethyl)phenyl] methyl sulfide

3,5-bis(trifluoromethyl)thiophenol

methyl iodide

Downstream raw materials:

1,1-Diphenylethylene

benzyl 3,5-bis(trifluoromethyl)phenyl sulfone

Refernces

• 1、 Nambo, Masakazu,Keske, Eric C.,Rygus, Jason P. G.,Yim, Jacky C.-H.,Crudden, Cathleen M.. "Development of Versatile Sulfone Electrophiles for Suzuki-Miyaura Cross-Coupling Reactions". . p. 1108 - 1112. Retrieved 2017/08/09.