2-(2-Thienyl)thiazole

Base Information

• Chemical Name: 2-(2-Thienyl)thiazole
• CAS No.: 42140-95-4
• Molecular Formula: C₇H₅NS₂
• Molecular Weight: 167.255
• Hs Code.: 2934999090
• Mol file: 42140-95-4.mol

Synonyms:

Chemical Property of 2-(2-Thienyl)thiazole

Chemical Property:

• PSA: 69.37000
• LogP: 2.87160

Purity/Quality:

95% ^*data from raw suppliers

2-(2-Thienyl)thiazole 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Thienyl)thiazole

There total 12 articles about 2-(2-Thienyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + 2-(trimethylstannyl)thiophene (37496-13-2) → 2-(thiophen-2-yl)thiazole (42140-95-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; at 100 ℃; Inert atmosphere;

DOI:10.1021/cm9029038

Reference yield: 90.0%

4,5-dihydro-2-(2-thienyl)-1,3-thiazole (60705-34-2) → 2-(thiophen-2-yl)thiazole (42140-95-4)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 10h; Molecular sieve;

DOI:10.1002/asia.201300267

Reference yield: 89.0%

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + 2-thiopheneboronic acid pinacol ester (193978-23-3) → 2-(thiophen-2-yl)thiazole (42140-95-4)

Guidance literature:

With potassium phosphate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; water; toluene; at 60 ℃; for 3h; Reagent/catalyst; Temperature; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.5b02689

upstream raw materials:

thiophene

2-thiazolylamine

2-thiophen-2-yl-thiazole-4,5-dicarboxylic acid

2-bromothiophene

Downstream raw materials:

2,5-di-(2-thienyl)thiazole

Refernces

• 1、 Matsushita, Kaoru,Takise, Ryosuke,Hisada, Tomoya,Suzuki, Shin,Isshiki, Ryota,Itami, Kenichiro,Muto, Kei,Yamaguchi, Junichiro. "Pd-Catalyzed Decarbonylative C?H Coupling of Azoles and Aromatic Esters". supporting information. p. 2393 - 2396. Retrieved 2018/05/30.
• 2、 Li, Xiangnan,Li, Cheng,Yin, Bing,Li, Cong,Liu, Ping,Li, Jianli,Shi, Zhen. "DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles". . p. 1408 - 1411. Retrieved 2013/07/26.