5-chloro-N-methylpyridin-2-amine

Base Information

• Chemical Name: 5-chloro-N-methylpyridin-2-amine
• CAS No.: 4214-80-6
• Molecular Formula: C6H7ClN2
• Molecular Weight: 142.588
• Hs Code.: 2933399090
• European Community (EC) Number: 867-605-7
• DSSTox Substance ID: DTXSID90397113
• Nikkaji Number: J1.293.506D
• Wikidata: Q72454850
• Mol file: 4214-80-6.mol

Synonyms:5-chloro-N-methylpyridin-2-amine;4214-80-6;5-Chloro-2-methylaminopyridine;5-Chloro-N-methyl-2-pyridineamine;5-Chloro-2-(methylamino)pyridine;SCHEMBL1503953;DTXSID90397113;Methyl(5-chloro-2-pyridyl)amine;5-chloro-N-methyl-2-pyridinamine;KSISYWKRGRATSK-UHFFFAOYSA-N;MFCD00955783;AKOS000431604;AB07756;DS-7043;CS-0151239;FT-0664767;EN300-72983;C75129;A872943;J-501574;Z359297632

Chemical Property of 5-chloro-N-methylpyridin-2-amine

Chemical Property:

• Melting Point: 63-65°C
• Boiling Point: 247℃
• Flash Point: 103℃
• PSA: 28.15000
• Density: 1.250
• LogP: 1.19860
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: DMSO, Methanol
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 142.0297759
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2-methylaminopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=NC=C(C=C1)Cl
• Uses: 5-Chloro-2-methylaminopyridine is used in the preparation of aminosulfuranes with N-heterocyclic groups.

Technology Process of 5-chloro-N-methylpyridin-2-amine

There total 6 articles about 5-chloro-N-methylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-<(benzotriazol-1-yl)methylamino>-5-chloropyridine (111098-22-7) → 5-chloro-2-(methylamino)pyridine (4214-80-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; for 8h; Heating;

Reference yield: 84.0%

1-[(5-chloropyridin-2-yl)methylamino]pyridinium iodide → 5-chloro-2-(methylamino)pyridine (4214-80-6)

Guidance literature:

With acetic acid; zinc; at 20 ℃; for 29h;

DOI:10.1016/S0040-4020(00)00084-3

Reference yield: 78.0%

5-chloro-2-pyridylamine (1072-98-6) + methanol (67-56-1) → 5-chloro-2-(methylamino)pyridine (4214-80-6)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydroxide; In methanol; at 150 ℃; for 12h;

DOI:10.1039/d1cc05076a

upstream raw materials:

2-<(benzotriazol-1-yl)methylamino>-5-chloropyridine

pyridinium N-(5'-chloropyridin-2'-yl)aminide

5-chloro-2-pyridylamine

bis(methoxy)methylborane

Downstream raw materials:

methyl 5-chloro-2-{[(5-chloropyridin-2-yl)(methyl)amino]methyl}benzoate

3-(N-(5-chloropyridin-2-yl)-N-methylsulfamoyl)benzoic acid

C₁₉H₁₈ClN₅O₂

Refernces

• 1、 -. "COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES". Page/Page column 126. . Retrieved 2014/06/11.
• 2、 Martínez-Barrasa, Valentín,Delgado, Francisca,Burgos, Carolina,Luis García-Navío,Luisa Izquierdo,Alvarez-Builla, Julio. "Pyridinium N-,(2'-azinyl)aminides: Regioselective synthesis of 2- alkylaminoazines". . p. 2481 - 2490. Retrieved 2007/10/03.