2-Bromo-2'-nitroacetophenone

Base Information

• Chemical Name: 2-Bromo-2'-nitroacetophenone
• CAS No.: 6851-99-6
• Molecular Formula: C8H6BrNO3
• Molecular Weight: 244.045
• Hs Code.: 29147000
• Mol file: 6851-99-6.mol

Synonyms:Acetophenone,2-bromo-2'-nitro- (6CI,7CI,8CI);2-Bromo-1-(2-nitrophenyl)ethanone;2-Nitrophenacyl bromide;NSC 54389;o-Nitrophenacyl bromide;a-Bromo-2-nitroacetophenone;a-Bromo-o-nitroacetophenone;

Chemical Property of 2-Bromo-2'-nitroacetophenone

Chemical Property:

• Appearance/Colour: white to pale yellow crystalline powder
• Melting Point: 55-57 °C(lit.)
• Boiling Point: 335.7 °C at 760 mmHg
• Flash Point: 156.9 °C
• PSA: 62.89000
• Density: 1.671 g/cm³
• LogP: 2.69560
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Chloroform, Methanol

Purity/Quality:

99% ^*data from raw suppliers

Bromo-2’-nitroacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Bromo-2'-nitroacetophenone is used in the novel synthesis of 5-pyridylindolizine derivatives. 2-Bromo-2′-nitroacetophenone, an electroactive derivative-forming reagent, was used as a precolumn reagent for preparing prostaglandin derivatives.

Technology Process of 2-Bromo-2'-nitroacetophenone

There total 11 articles about 2-Bromo-2'-nitroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-acetylnitrobenzene (577-59-3) → 2-bromo-1-(2-nitrophenyl)ethanone (6851-99-6)

Guidance literature:

With aluminium trichloride; bromine; In diethyl ether;

DOI:10.1021/jo00177a010

Reference yield: 34.0%

2-nitrostyrene (579-71-5) → 2-bromo-1-(2-nitrophenyl)ethanone (6851-99-6)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; water; at 60 ℃; for 4h; Green chemistry;

DOI:10.1039/c6ob02200f

Reference yield: 6.0%

2-acetylnitrobenzene (577-59-3) → 2,2-dibromo-1-(2-nitrophenyl)ethan-1-one (35928-59-7) + 2-bromo-1-(2-nitrophenyl)ethanone (6851-99-6)

Guidance literature:

With bromine; In 1,4-dioxane; for 2h;

upstream raw materials:

2-acetylnitrobenzene

(2-nitrobenzoyl)diazomethane

bromine

acetic acid

Downstream raw materials:

2,6-dimethyl-4-(2-nitro-phenacylmercapto)-pyrylium; bromide

2-(2-nitro-benzoyl)-benzofuran-3-carboxylic acid ethyl ester

2-(2-nitro-phenyl)-imidazo[1,2-a]pyridine

1-(2-amino-phenyl)-2-bromo-ethanone

Refernces

• 1、 Bantzi, Marina,Augsburger, Fiona,Loup, Jérémie,Berset, Yan,Vasilakaki, Sofia,Myrianthopoulos, Vassilios,Mikros, Emmanuel,Szabo, Csaba,Bochet, Christian G.. "Novel Aryl-Substituted Pyrimidones as Inhibitors of 3-Mercaptopyruvate Sulfurtransferase with Antiproliferative Efficacy in Colon Cancer". . p. 6221 - 6240. Retrieved 2021/05/06.
• 2、 Zhang, Jinhao,Jing, Nannan,Fan, Xinli,Tang, Xinjing. "Photoregulation of Gene Expression with Amantadine-Modified Caged siRNAs through Host–Guest Interactions". supporting information. p. 14002 - 14010. Retrieved 2020/10/02.