1-Isocyano-2-methoxyethane

Base Information

• Chemical Name: 1-Isocyano-2-methoxyethane
• CAS No.: 43219-50-7
• Molecular Formula: C4H7NO
• Molecular Weight: 85.1057
• Hs Code.: 2926909090
• European Community (EC) Number: 695-579-5
• DSSTox Substance ID: DTXSID90377955
• Nikkaji Number: J1.097.199C
• Wikidata: Q72489825
• Mol file: 43219-50-7.mol

Synonyms:1-isocyano-2-methoxyethane;43219-50-7;2-Methoxyethylisocyanide;2-Methoxyethyl isocyanide;2-(methoxy)ethyl-isonitrile;DTXSID90377955;BBL021375;MFCD06200529;STK894087;AKOS005144119;GS-0307;1-isocyano-2-methoxyethane, AldrichCPR;EN300-1842006

Chemical Property of 1-Isocyano-2-methoxyethane

Chemical Property:

• PSA: 9.23000
• LogP: -0.21720
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 85.052763847
• Heavy Atom Count: 6
• Complexity: 61.2

Purity/Quality:

95% ^*data from raw suppliers

1-Isocyano-2-methoxyethane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC[N+]#[C-]
• Uses: 1-Isocyano-2-methoxyethane is used in preparation of Chitosan-coated liposomes as novel carrier system for mucoadhesive liposomes loaded with antiviral drug triazavirin.

Technology Process of 1-Isocyano-2-methoxyethane

There total 1 articles about 1-Isocyano-2-methoxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-formyl-O-methylethanolamine (43219-53-0) → 2-methoxyethyl isocyanide (43219-50-7)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide;

DOI:10.1002/hlca.19730560524

Reference yield: 96.0%

tert-butyl 6-methyl-4-[(2-nitrobenzene)sulfonyl]-1,2,3,4-tetrahydropyrazine-1-carboxylate (1489247-05-3) + 2-methoxyethyl isocyanide (43219-50-7) → N-methoxyethyl-2-methyl-4-[(2-nitrophenyl)sulfonyl]-1-(trifluoroacetyl) piperazine-2-carboxamide

Guidance literature:

tert-butyl 6-methyl-4-[(2-nitrobenzene)sulfonyl]-1,2,3,4-tetrahydropyrazine-1-carboxylate; With trifluoroacetic acid; at 20 ℃;

2-methoxyethyl isocyanide; In ethanol; at 0 - 20 ℃;

DOI:10.1002/chem.201900815

Reference yield: 94.0%

PHTHALAZINE (253-52-1) + Benzylidenemalononitrile (2700-22-3) + 2-methoxyethyl isocyanide (43219-50-7) → 3-(2-methoxyethylamino)-2-phenylpyrrolo[2,1-a]phthalazine-1-carbonitrile

Guidance literature:

In water; acetonitrile; at 25 - 30 ℃; for 18h;

DOI:10.1007/s10593-017-2071-3

upstream raw materials:

N-formyl-O-methylethanolamine

Downstream raw materials:

C₁₇H₁₇ClN₂O₂

Refernces

• 1、 Hao, Guiyang,Zang, Jianying,Liu, Boli. "Preparation and biodistribution of novel 99mTc(CO) 3-CNR complexes for myocardial imaging". . p. 13 - 18. Retrieved 2007/10/03.