2' 4'-DIHYDROXY-5'-NITROACETOPHENONE

Base Information

• Chemical Name: 2' 4'-DIHYDROXY-5'-NITROACETOPHENONE
• CAS No.: 3328-77-6
• Molecular Formula: C8H7NO5
• Molecular Weight: 197.147
• Hs Code.: 2914700090
• Mol file: 3328-77-6.mol

Synonyms:Acetophenone,2',4'-dihydroxy-5'-nitro- (6CI,7CI,8CI);2,4-Dihydroxy-5-nitroacetophenone;5-Nitroresacetophenone;NSC 3928;

Chemical Property of 2' 4'-DIHYDROXY-5'-NITROACETOPHENONE

Chemical Property:

• Vapor Pressure: 2.59E-05mmHg at 25°C
• Melting Point: 142-146 °C
• Refractive Index: 1.637
• Boiling Point: 347.9 °C at 760 mmHg
• Flash Point: 155.8 °C
• PSA: 103.35000
• Density: 1.52 g/cm³
• LogP: 1.73180

Purity/Quality:

99% ^*data from raw suppliers

1-(2,4-DIHYDROXY-5-NITROPHENYL)ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2' 4'-DIHYDROXY-5'-NITROACETOPHENONE

There total 9 articles about 2' 4'-DIHYDROXY-5'-NITROACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2',4'-dihydroxy-4-acetophenone (89-84-9) → 1-(2,4-dihydroxy-5-nitrophenyl)ethanone (3328-77-6)

Guidance literature:

With zirconyl nitrate; In acetone; at 50 ℃; for 5h;

DOI:10.1016/j.tetlet.2006.02.057

Reference yield:

recorcinol (108-46-3) → 1-(2,4-dihydroxy-5-nitrophenyl)ethanone (3328-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ZnCl₂ / entsteht nicht Resacetophenon, sondern wesentlich Resodiacetophenon

2: nitric acid

With nitric acid; zinc(II) chloride;

Reference yield:

1-(4-benzyloxy-2-hydroxy-5-nitro-phenyl)-ethanone (101097-87-4) → 1-(2,4-dihydroxy-5-nitrophenyl)ethanone (3328-77-6)

Guidance literature:

With hydrogen bromide; acetic acid;

upstream raw materials:

2',4'-dihydroxy-4-acetophenone

1-(4-benzyloxy-2-hydroxy-5-nitro-phenyl)-ethanone

bis-(5-acetyl-2,4-dihydroxy-phenyl)-sulfide

4-nitroresorcinol

Downstream raw materials:

4-acetyl-3-hydroxy-6-nitro-2-phenyliodonio-phenolate

3-benzoyl-7-hydroxy-6-nitroflavone

Refernces

• 1、 Mondal, Mohabul A,Mandal, Debashis,Mitra, Kanchan. "Yttrium Nitrate mediated Nitration of Phenols at room temperature in Glacial Acetic acid". . p. 39 - 43. Retrieved 2017/01/24.
• 2、 Cushman, Mark,Zhu, Helen,Geahlen, Robert L.,Kraker, Alan J.. "Synthesis and Biochemical Evaluation of a Series of Aminoflavones as Potential Inhibitors of Protein-Tyrosine Kinases p56lek, EGFr, and p60v-src". . p. 3353 - 3362. Retrieved 2007/10/02.