Hexanoic acid, 2-methylene-

Base Information

• Chemical Name: Hexanoic acid, 2-methylene-
• CAS No.: 4380-88-5
• Molecular Formula: C7H12O2
• Molecular Weight: 128.171
• Mol file: 4380-88-5.mol

Synonyms:2-n-butyl acrylic acid;2-methylenehexanoic acid;2-methylene-hexanoic acid;α-n-butylacrylic acid;2-butylpropenoic acid;α-butylacrylic acid;

Chemical Property of Hexanoic acid, 2-methylene-

Chemical Property:

• Melting Point: -15 °C
• Boiling Point: 69-70 °C(Press: 0.2 Torr)
• PSA: 37.30000
• Density: 0.9513 g/cm3
• LogP: 1.81740

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hexanoic acid, 2-methylene-

There total 6 articles about Hexanoic acid, 2-methylene- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

carbon monoxide (201230-82-2) + hex-1-yne (693-02-7) → 2-methyl-2-hexenoic acid (28897-58-7) + 2-butylacrylic acid (4380-88-5)

Guidance literature:

With sodium hydroxide; cetyltrimethylammonim bromide; nickel cyanide; In toluene; at 90 ℃; for 5h; under 760 Torr;

DOI:10.1016/0022-328X(90)85154-Q

Reference yield: 8.0%

2-trifluoromethylsulfonyloxy-1-hexene (37555-23-0) + carbon dioxide (124-38-9,18923-20-1) → 1-hexene (592-41-6,25067-06-5) + 2-butylacrylic acid (4380-88-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; tetrabutylammonium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; under 760 Torr; electrolyses, carbon cathode, Mg anode, E=-2.2 V;

DOI:10.1055/s-1997-3241

Reference yield:

carbon monoxide (201230-82-2) + hex-1-yne (693-02-7) → E-hept-2-enoic acid (10352-88-2) + 2-butylacrylic acid (4380-88-5)

Guidance literature:

With C₄₂H₃₈O₄P₂S; water; palladium diacetate; In 1-methyl-pyrrolidin-2-one; under 7500.75 Torr; Overall yield = 82 percentChromat.; Autoclave;

DOI:10.1039/c9gc01887e

upstream raw materials:

carbon monoxide

hex-1-yne

ethanol

2-n-butylacrolein

Downstream raw materials:

n-hexan-2-one

valeric acid

2(R)-(N-benzyloxyamino-methyl)-hexanoic acid

4S-benzyl-3-(2-butyl-acryloyl)-5,5-dimethyl-oxazolidin-2-one

Refernces

• 1、 Yang, Da,Liu, Huan,Liu, Lei,Guo, Wen-Di,Lu, Yong,Liu, Ye. "Co-catalysis over a tri-functional ligand modified Pd-catalyst for hydroxycarbonylation of terminal alkynes towards α,β-unsaturated carboxylic acids". . p. 5336 - 5344. Retrieved 2019/10/11.
• 2、 Jutand, Anny,Négri, Serge. "Palladium-Catalyzed Carboxylation of Vinyl Triflates. Electrosynthesis of α, β-Unsaturated Carboxylic Acids". . p. 719 - 721. Retrieved 2007/10/03.