Technology Process of 2-broMo-3-forMylbenzonitrile
There total 5 articles about 2-broMo-3-forMylbenzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
silica gel; pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1016/j.bmcl.2010.12.034
- Guidance literature:
-
2-iodo-3-methylbenzonitrile;
With
N-Bromosuccinimide; dibenzoyl peroxide;
In
tetrachloromethane;
at 85 ℃;
for 22h;
Inert atmosphere;
With
sodium hydrogencarbonate;
In
dimethyl sulfoxide;
at 20 - 100 ℃;
Inert atmosphere;
With
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
dimethyl sulfoxide;
at 65 ℃;
for 0.666667h;
Inert atmosphere;
DOI:10.1021/ol801986m
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 1 h / 80 °C
2: lithium hydroxide / tetrahydrofuran; methanol; water / 1 h / 20 °C
3: silica gel; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C
With
silica gel; pyridinium chlorochromate; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.12.034
