3-IMINO-2-INDOLINONE

Base Information

• Chemical Name: 3-IMINO-2-INDOLINONE
• CAS No.: 612-53-3
• Molecular Formula: C8H6 N2 O
• Molecular Weight: 146.148
• Mol file: 612-53-3.mol

Synonyms:2-Indolinone,3-imino- (8CI); Oxindole, 3-imino- (4CI); Imesatin; NSC 15435

Chemical Property of 3-IMINO-2-INDOLINONE

Chemical Property:

• Vapor Pressure: 6.94E-05mmHg at 25°C
• Boiling Point: 343.7°C at 760 mmHg
• Flash Point: 161.6°C
• PSA: 52.95000
• Density: 1.41g/cm³
• LogP: 1.24430

Purity/Quality:

98%min ^*data from raw suppliers

3-IMINO-2-INDOLINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-IMINO-2-INDOLINONE

There total 2 articles about 3-IMINO-2-INDOLINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isatin-3-(N4-benzylthiosemicarbazone) (28492-94-6,101306-61-0) → (E)-3-iminoindolin-2-one (612-53-3) + 4-Phenyl-3-thiosemicarbazide (5351-69-9)

Guidance literature:

In dimethyl sulfoxide; Electrolysis; Inert atmosphere;

DOI:10.1007/s12039-021-01970-x

Reference yield:

indole-2,3-dione 3-thiosemicarbazone (1165809-20-0) → (E)-3-iminoindolin-2-one (612-53-3) + thiosemicarbazide (79-19-6)

Guidance literature:

In dimethyl sulfoxide; Electrolysis; Inert atmosphere;

DOI:10.1007/s12039-021-01970-x

Reference yield: 98.0%

(E)-3-iminoindolin-2-one (612-53-3) + 3-oxo-3-phenylpropionic acid (614-20-0) → (S)-3-amino-3-(2-oxo-2-phenylethyl)indolin-2-one

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); (4R,4'R)-2,2'-(propane-2,2'diyl)bis(4-phenyl-4,5-dihydrooxazole); In dichloromethane; at -40 ℃; for 48h; enantioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02306

upstream raw materials:

indole-2,3-dione 3-thiosemicarbazone

isatin-3-(N⁴-benzylthiosemicarbazone)

Downstream raw materials:

1,2,3,4-tetrahydro-quinazoline-2,4-dione

N-carbamoyl-anthranilic acid amide

indole-2,3-dione

quinazoline-2,4-diol

Refernces