4-Acetamido-5-chloro-2-methoxybenzoyl chloride

Base Information

• Chemical Name: 4-Acetamido-5-chloro-2-methoxybenzoyl chloride
• CAS No.: 4516-32-9
• Molecular Formula: C10H9Cl2NO3
• Molecular Weight: 262.092
• DSSTox Substance ID: DTXSID00464123
• Wikidata: Q82289327
• Mol file: 4516-32-9.mol

Synonyms:4-acetylamino-5-chloro-2-methoxybenzoyl chloride;4-Acetamido-5-chloro-2-methoxybenzoyl chloride;4516-32-9;2-methoxy-4-acetamido-5chlorobenzoyl chloride;4-acetylamino-5-chloro-2-methoxy-benzoyl chloride;SCHEMBL6962669;DTXSID00464123;YBCOOGQGBVDQSB-UHFFFAOYSA-N;4-acetylamino-5-chloro-2-methoxy benzoyl chloride

Chemical Property of 4-Acetamido-5-chloro-2-methoxybenzoyl chloride

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 260.9959485
• Heavy Atom Count: 16
• Complexity: 285

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=C(C(=C1)OC)C(=O)Cl)Cl

Technology Process of 4-Acetamido-5-chloro-2-methoxybenzoyl chloride

There total 3 articles about 4-Acetamido-5-chloro-2-methoxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(acetylamino)-5-chloro-2-methoxybenzoic acid (24201-13-6) → 4-acetylamino-5-chloro-2-methoxy-benzoyl chloride (4516-32-9)

Guidance literature:

Reference yield:

4-amino-5-chloro-2-methoxybenzoic acid (7206-70-4) → 4-acetylamino-5-chloro-2-methoxy-benzoyl chloride (4516-32-9)

Guidance literature:

4-amino-5-chloro-2-methoxybenzoic acid; With triethylamine; In DMF (N,N-dimethyl-formamide);

With chloroformic acid ethyl ester; In DMF (N,N-dimethyl-formamide); toluene; Product distribution / selectivity;

Reference yield:

→ 4-acetylamino-5-chloro-2-methoxy-benzoyl chloride (4516-32-9)

Guidance literature:

Aus d. entspr. Saeure, SOCl2;

upstream raw materials:

4-(acetylamino)-5-chloro-2-methoxybenzoic acid

4-amino-5-chloro-2-methoxybenzoic acid

Downstream raw materials:

4-Acetylamino-5-chloro-2-methoxy-N-(1R,9aR)-octahydro-quinolizin-1-yl-benzamide

4-Acetylamino-5-chloro-2-methoxy-N-(1R,9aS)-octahydro-quinolizin-1-yl-benzamide

4-amino-5-chloro-2-methoxy-N-(4-methyl-piperazin-1-yl)-benzamide

4-acetylamino-5-chloro-2-methoxy-N-[4-(3-methylbutyl)-1-piperazinyl]benzamide

Refernces

• 1、 -. "Synthesis". Page/Page column 11. . Retrieved 2010/02/11.
• 2、 -. "Pharmaceutically active tropanes". . . Retrieved 2008/06/13.