3,5-Dimethylmorpholine

Base Information

• Chemical Name: 3,5-Dimethylmorpholine
• CAS No.: 123-57-9
• Molecular Formula: C6H13NO
• Molecular Weight: 115.175
• Hs Code.: 2934999090
• European Community (EC) Number: 802-859-4
• NSC Number: 28666
• DSSTox Substance ID: DTXSID50274491
• Nikkaji Number: J2.038.435B
• Mol file: 123-57-9.mol

Synonyms:3,5-Dimethylmorpholine;123-57-9;3,5-Dimethyl-morpholine;Morpholine, 3,5-dimethyl-;MFCD00065032;MFCD14586370;67804-26-6;NSC28666;Morpholine,5-dimethyl-;SCHEMBL92625;DTXSID50274491;NSC-28666;3,5-Dimethyl-morpholine, AldrichCPR;AKOS006283288;AB02607;MB13620;SB12134;SB19931;SB37836;BS-12812;SY039541;CS-0075433;EN300-84694;P10582;F8889-2854

Chemical Property of 3,5-Dimethylmorpholine

Chemical Property:

• Vapor Pressure: 3.78mmHg at 25°C
• Melting Point: 202-203 °C(Solv: ethanol (64-17-5))
• Refractive Index: 1.406
• Boiling Point: 150.8 °C at 760 mmHg
• PKA: 9.09±0.60(Predicted)
• Flash Point: 50.1 °C
• PSA: 21.26000
• Density: 0.862g/cm³
• LogP: 0.71200
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 66.9

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Dimethyl-morpholine AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1COCC(N1)C
• Uses: 3,5-Dimethylmorpholine it is used in preparation of Quinoline-based derivatives.

Technology Process of 3,5-Dimethylmorpholine

There total 6 articles about 3,5-Dimethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3,5-dimethylmorpholin-4-yl)benzonitrile (313974-82-2) → 2,6-dimethylmorpholine (123-57-9,942400-51-3) + 4-fluorobenzonitrile (1194-02-1,143234-87-1)

Guidance literature:

Reference yield:

N-nitroso-trans-2,6-dimethylmorpholine (55556-87-1) → trans-2,6-dimethylmorpholine (123-57-9,45597-00-0,67804-26-6,942400-51-3)

Guidance literature:

With perchloric acid; ammonium sulfamate; sodium thiocyanide; at 50 ℃; Rate constant;

DOI:10.1021/jo01312a022

Reference yield:

2-Amino-1-propanol (6168-72-5) + hydroxy-2-propanone (116-09-6) → 2,6-dimethylmorpholine (123-57-9,942400-51-3)

Guidance literature:

2-Amino-1-propanol; hydroxy-2-propanone; With hydrogen; platinum(IV) oxide; In ethanol; at 20 ℃; under 1991.07 Torr;

With sulfuric acid; at 180 ℃; for 8h;

With potassium hydroxide; In water; at 20 ℃;

upstream raw materials:

bis(2-hydroxy-1-methylethyl)amine

2-Amino-1-propanol

hydroxy-2-propanone

4-(3,5-dimethylmorpholin-4-yl)benzonitrile

Downstream raw materials:

4-(fluoro-phenyl-acetyl)-2,6-dimethyl-morpholine

3,5-dimethyl-4-(3,4,5-trimethoxy-benzoyl)-morpholine

Rifamycin-B-(2,6-dimethyl-morpholid)

4-[2-(1H-imidazole-2-carbonyl)-benzoyl]-3,5-dimethyl-morpholine

Refernces

• 1、 -. "NUCLEAR TRANSPORT MODULATORS AND USES THEREOF". Paragraph 00289. . Retrieved 2013/12/03.
• 2、 -. "Imidazole derivatives". . . Retrieved 2008/06/13.