2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 4546-48-9
• Molecular Formula: C17H13NO2
• Molecular Weight: 263.296
• Hs Code.: 2933499090
• Mol file: 4546-48-9.mol

Synonyms:4-Quinolinecarboxylic acid, 2-phenyl-, methyl ester;Cinchophen methyl derivative;4-Quinolinecarboxylic acid,2-phenyl-,methyl ester;Methyl 2-phenyl-4-quinolinecarboxylate;4-methoxycarbonyl-2-phenylquinoline;2-phenyl-4-quinolinecarboxylic acid methyl ester;2-phenyl-4-(methylcarboxylate)quinoline;2-Phenyl-quinoline-4-carboxylic acid methyl ester;2-phenyl-4-(methoxycarbonyl)quinoline;

Chemical Property of 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 1.26E-07mmHg at 25°C
• Melting Point: 60-62oC(lit.)
• Boiling Point: 430.8oC at 760 mmHg
• Flash Point: 214.4oC
• PSA: 39.19000
• Density: 1.197g/cm3
• LogP: 3.68840

Purity/Quality:

98.5% ^*data from raw suppliers

Methyl 2-phenyl-4-quinolinecarboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER

There total 29 articles about 2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + cinchophen (132-60-5) → methyl 2-phenylquinoline-4-carboxylate (4546-48-9)

Guidance literature:

With sulfuric acid; Reflux;

Reference yield: 92.0%

pyruvic acid methyl ester (600-22-6) + benzaldehyde (100-52-7) + aniline (62-53-3) → methyl 2-phenylquinoline-4-carboxylate (4546-48-9)

Guidance literature:

With zirconocene dichloride; 1,2,4-benzene tricarboxylic acid; copper(II) oxide; In water; isopropyl alcohol; at 60 ℃; for 2h; Reagent/catalyst; Solvent; Catalytic behavior; Green chemistry;

DOI:10.1039/c7ra00870h

Reference yield: 92.0%

pyruvic acid methyl ester (600-22-6) + benzylidene phenylamine (538-51-2) → methyl 2-phenylquinoline-4-carboxylate (4546-48-9)

Guidance literature:

With zirconocene dichloride; 1,2,4-benzene tricarboxylic acid; copper(II) oxide; In water; isopropyl alcohol; at 60 ℃;

DOI:10.1039/c7ra00870h

upstream raw materials:

cinchophen

methanol

2-phenylquinoline-4-carbonyl chloride

methyl 2-phenylquinoline-4-carboxylate 1-oxide

Downstream raw materials:

2-(2-phenyl-[4]quinolyl)-propan-2-ol

methyl 2-phenylquinoline-4-carboxylate 1-oxide

2-phenylquinoline-4-carboxylic acid hydrazide

Refernces

• 1、 Echeverry-Gonzalez, Carlos A.,Ortiz Villamizar, Marlyn Catalina,Kouznetsov, Vladimir V.. "The remarkable selectivity of the 2-arylquinoline-based acyl hydrazones toward copper salts: Exploration of their catalytic applications in the copper catalysed: N -arylation of indole derivatives and C1-alkynylation of tetrahydroisoquinolines via the A supporting information. p. 243 - 250. Retrieved 2021/01/11.
• 2、 Wan, Jie-Ping,Yang, Lu. "Ethyl lactate-involved three-component dehydrogenative reactions: Biomass feedstock in diversity-oriented quinoline synthesis". supporting information. p. 3074 - 3078. Retrieved 2020/06/25.