Benzene, 1-fluoro-4-(fluoromethyl)-

Base Information

• Chemical Name: Benzene, 1-fluoro-4-(fluoromethyl)-
• CAS No.: 459-51-8
• Molecular Formula: C7H6F2
• Molecular Weight: 128.121
• Mol file: 459-51-8.mol

Synonyms:

Chemical Property of Benzene, 1-fluoro-4-(fluoromethyl)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-fluoro-4-(fluoromethyl)-

There total 12 articles about Benzene, 1-fluoro-4-(fluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-Fluorobenzyl bromide (459-46-1) → 1-fluoro-4-(fluoromethyl)benzene (459-51-8)

Guidance literature:

With 1-butyl-3-methyl-3H-imidazol-1-ium fluoride; In neat (no solvent); at 80 ℃; for 0.5h; Microwave irradiation; Green chemistry;

DOI:10.1016/j.tetlet.2013.12.020

Reference yield: 27.4%

p-fluorotoluene (352-32-9) → 4-fluoro-α,α-difluorotoluene (26132-51-4) + 1-fluoro-4-(fluoromethyl)benzene (459-51-8) + 3-Methyl-3,6,6-trifluoro-1,4-cyclohexadiene (195886-85-2) + 3-Fluoromethyl-3,6,6-trifluoro-1,4-cyclohexadiene

Guidance literature:

With tetraethylammonium fluoride; In acetonitrile; Further byproducts given; Ambient temperature; electrolysis: smooth platinum sheets as the anode and the cathode, Ag/AgClO₄ as a reference electrode, 2.5 V, 2.7 F/mol;

DOI:10.1016/S0022-1139(97)00141-3

Reference yield: 27.4%

p-fluorotoluene (352-32-9) → 1-fluoro-4-(fluoromethyl)benzene (459-51-8) + 3-Methyl-3,6,6-trifluoro-1,4-cyclohexadiene (195886-85-2) + 3-Fluoromethyl-3,6,6-trifluoro-1,4-cyclohexadiene + 3-Difluoromethyl-3,6,6-trifluoro-1,4-cyclohexadiene

Guidance literature:

With tetraethylammonium fluoride; In acetonitrile; Further byproducts given; Ambient temperature; electrolysis: smooth platinum sheets as the anode and the cathode, Ag/AgClO₄ as a reference electrode, 2.5 V, 2.7 F/mol;

DOI:10.1016/S0022-1139(97)00141-3

upstream raw materials:

fluorobenzene

fluoromethyl alcohol

(E)-3-Ureido-but-2-enoic acid ethyl ester

4-Fluorobenzyl bromide

Downstream raw materials:

N-(4-fluorobenzyl)-4-methyl-2-nitroaniline

1-(but-3-en-1-yl)-4-fluorobenzene

Refernces

• 1、 Britton, Robert,Friesen, Chadron M.,Jelier, Benson J.,Martin, Rainer E.,Meanwell, Michael,Newton, Josiah J.. "Quaternary Ammonium Trifluoromethoxide Salts as Stable Sources of Nucleophilic OCF3". supporting information. p. 1785 - 1790. Retrieved 2020/03/24.
• 2、 Guo, Jing,Bamford, Karlee L.,Stephan, Douglas W.. "9-Borabicyclo[3.3.l]nonane-induced Friedel-Crafts benzylation of arenes with benzyl fluorides". supporting information. p. 5258 - 5261. Retrieved 2019/06/07.