Hydrocotoin

Base Information

• Chemical Name: Hydrocotoin
• CAS No.: 34425-64-4
• Molecular Formula: C₁₅H₁₄O₄
• Molecular Weight: 258.274
• Mol file: 34425-64-4.mol

Synonyms:

Chemical Property of Hydrocotoin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hydrocotoin

There total 21 articles about Hydrocotoin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

bromobenzene (108-86-1,52753-63-6) + 5,7-dimethoxy-2,2-dimethylbenzo[1,3]dioxin-4-one (1064710-37-7) → 2-hydroxy-4,6-dimethoxybenzophenone (34425-64-4)

Guidance literature:

bromobenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

5,7-dimethoxy-2,2-dimethylbenzo[1,3]dioxin-4-one; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-2008-1078597

Reference yield: 65.0%

3,5-dimethoxyphenol (500-99-2) + benzaldehyde (100-52-7) → 2-hydroxy-4,6-dimethoxybenzophenone (34425-64-4)

Guidance literature:

With [(C₆H₆)(PCy₃)(CO)RuH]⁺*BF₄^?; potassium carbonate; triphenylphosphine; In chlorobenzene; at 110 ℃; for 16h; regioselective reaction; Schlenk technique;

DOI:10.1002/ejoc.201403518

Reference yield: 47.0%

Benzoic acid 2-bromo-3,5-dimethoxy-phenyl ester (129103-80-6) → 2-hydroxy-4,6-dimethoxybenzophenone (34425-64-4)

Guidance literature:

With sec.-butyllithium; In tetrahydrofuran; diethyl ether; hexane; a) -100 deg C, 1 h, b) -70 deg C, 2 h;

DOI:10.1021/jo00302a011

upstream raw materials:

diazomethane

diethyl ether

cotoin

2-benzoylphloroglucinol

Downstream raw materials:

2,3,4-trichloro-1,5-dimethoxy-benzene

benzoyl chloride

Benzotrichlorid

benzoic acid

Refernces

• 1、 Xiao, Lin,Lang, Tao-Tao,Jiang, Ying,Zang, Zhong-Lin,Zhou, Cheng-He,Cai, Gui-Xin. "Aerobic Copper-Catalyzed Salicylaldehydic Cformyl?H Arylations with Arylboronic Acids". supporting information. p. 3278 - 3283. Retrieved 2021/02/01.
• 2、 Lee, Hanbin,Yi, Chae S.. "Synthesis of 2-acylphenol and flavene derivatives from the ruthenium-catalyzed oxidative c-h acylation of phenols with aldehydes". supporting information. p. 1899 - 1904. Retrieved 2015/03/18.