4-Methylheptanedioic acid dimethyl ester

Base Information

• Chemical Name: 4-Methylheptanedioic acid dimethyl ester
• CAS No.: 4751-49-9
• Molecular Formula: C10H18O4
• Molecular Weight: 202.24800
• Mol file: 4751-49-9.mol

Synonyms:

Chemical Property of 4-Methylheptanedioic acid dimethyl ester

Chemical Property:

• PSA: 52.60000
• LogP: 1.52890

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methylheptanedioic acid dimethyl ester

There total 7 articles about 4-Methylheptanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

methanol (67-56-1) + 3-methyl-1,3-pentadiene (4549-74-0) + carbon monoxide (201230-82-2) → dimethyl 4-methylheptanedioate (4751-49-9)

Guidance literature:

With palladium(II) trifluoroacetate; toluene-4-sulfonic acid; 1,2-bis[di(t-butyl)phosphinomethyl]benzene; In toluene; at 120 ℃; for 24h; under 30003 Torr; regioselective reaction; Autoclave; Green chemistry;

DOI:10.1002/anie.202015329

Reference yield:

sodium methylate (124-41-4) + 5-methyl-2-oxocyclohexanecarboxylic acid methyl ester (56576-40-0) → dimethyl 4-methylheptanedioate (4751-49-9)

Guidance literature:

DOI:10.1002/anie.200351266

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + methanol (67-56-1) + 3-methyl glutaric acid (626-51-7) → dimethyl 4-methylheptanedioate (4751-49-9)

Guidance literature:

Multistep reaction; (i) SOCl₂, (ii) /BRN= 102415/, (iii) /BRN= 1098229/, Et₃N, AgOAc;

DOI:10.1021/ja00840a048

upstream raw materials:

methanol

4-Methylpimelic acid dinitrile

diazomethane

3-methyl glutaric acid

Downstream raw materials:

2-hydroxy-5-methyl-cyclohexanecarbaldehyde

4-methyl-heptanedioic acid

Refernces

• 1、 Pidathala, Chandrakala,Hoang, Linh,Vignola, Nicola,List, Benjamin. "Direct catalytic asymmetric enolexo aldolizations". . p. 2785 - 2788. Retrieved 2007/10/03.