3-Fluoropyridine-4-carboxylic acid

Base Information

• Chemical Name: 3-Fluoropyridine-4-carboxylic acid
• CAS No.: 393-53-3
• Molecular Formula: C6H4FNO2
• Molecular Weight: 141.102
• Hs Code.: 2933399090
• Mol file: 393-53-3.mol

Synonyms:Isonicotinicacid, 3-fluoro- (8CI);3-Fluoropyridine-4-carboxylicacid;NSC 402974;

Chemical Property of 3-Fluoropyridine-4-carboxylic acid

Chemical Property:

• Appearance/Colour: white to yellow crystalline solid
• Vapor Pressure: 0.000559mmHg at 25°C
• Melting Point: 251-254 °C (dec.)
• Refractive Index: 1.541
• Boiling Point: 360 °C at 760 mmHg
• PKA: 2.85±0.10(Predicted)
• Flash Point: 171.5 °C
• PSA: 50.19000
• Density: 1.419 g/cm³
• LogP: 0.91890
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Fluoroisonicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, F
• Hazard Codes: Xi,F
• Statements: 36/37/38-10
• Safety Statements: 26-36-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-Fluoropyridine-4-carboxylic acid

There total 13 articles about 3-Fluoropyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-Fluoropyridine (372-47-4) + carbon dioxide (124-38-9,18923-20-1) → 3-fluoroisonicotinic acid (393-53-3)

Guidance literature:

3-Fluoropyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

carbon dioxide; In tetrahydrofuran; hexane;

DOI:10.1002/ejoc.200400895

Reference yield: 70.0%

carbon dioxide (124-38-9,18923-20-1) → 3-fluoroisonicotinic acid (393-53-3)

Guidance literature:

3-Fluoropyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1h;

carbon dioxide; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water; pH=5;

Reference yield: 51.0%

3-Fluoropyridine (372-47-4) → 3-fluoroisonicotinic acid (393-53-3)

Guidance literature:

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexane; at -75 ℃; for 3h;

DOI:10.1016/S0040-4020(01)80824-3

upstream raw materials:

3-fluoro-4-methylpyridine

3-Fluoropyridine

carbon dioxide

3-amino-4-methylpyridine

Downstream raw materials:

3-fluoropyridine-4-carbonyl chloride

3-[(2-methyl-4-iodophenyl)amino]isonicotinic acid

N-benzyl-N-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-3-fluoroisonicotinamide

3-Fluoropyridine

Refernces

• 1、 -. "HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND". Page/Page column 125-126. . Retrieved 2011/02/18.
• 2、 -. "COMPOSITION AND METHOD FOR CONTROLLING ARTHROPOD PESTS". Page/Page column 208-209. . Retrieved 2011/04/25.