Technology Process of 4-Cyclohexene-1,3-diol, 2,6-dimethyl-5-(phenylsulfonyl)-,
(1S,2S,3S,6R)-
There total 16 articles about 4-Cyclohexene-1,3-diol, 2,6-dimethyl-5-(phenylsulfonyl)-,
(1S,2S,3S,6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
formic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
DOI:10.1021/ol026377m
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran; diethyl ether / 0.5 h / -78 °C
1.2: 82 percent / tetrahydrofuran; diethyl ether / 8 h / 25 °C
2.1: Et3N; TMSOTf / CH2Cl2 / 4 h / Heating
2.2: 89 percent / aq. m-CPBA / CH2Cl2 / 6 h
3.1: 94 percent / tert-butyl hydroperoxide / Mo(CO)6 / benzene; decane / 1.5 h / Heating
4.1: methyllithium; CuI / tetrahydrofuran; diethyl ether; toluene / -30 - 0 °C
4.2: 92 percent / tetrahydrofuran; diethyl ether; toluene / -78 - 10 °C
5.1: 95 percent / PPh3; diethyl azodicarboxylate; HCO2H / tetrahydrofuran / 2 h / 20 °C
With
tert.-butylhydroperoxide; formic acid; trimethylsilyl trifluoromethanesulfonate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
copper(l) iodide; hexacarbonyl molybdenum; methyllithium;
In
tetrahydrofuran; diethyl ether; decane; dichloromethane; toluene; benzene;
5.1: Mitsunobu reaction;
DOI:10.1021/ol026377m
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 97 percent / LiHMDS / tetrahydrofuran / 0.25 h / -78 °C
2.1: 94 percent / tert-butyl hydroperoxide / Mo(CO)6 / benzene; decane / 1.5 h / Heating
3.1: methyllithium; CuI / tetrahydrofuran; diethyl ether; toluene / -30 - 0 °C
3.2: 92 percent / tetrahydrofuran; diethyl ether; toluene / -78 - 10 °C
4.1: 95 percent / PPh3; diethyl azodicarboxylate; HCO2H / tetrahydrofuran / 2 h / 20 °C
With
tert.-butylhydroperoxide; formic acid; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate;
copper(l) iodide; hexacarbonyl molybdenum; methyllithium;
In
tetrahydrofuran; diethyl ether; decane; toluene; benzene;
4.1: Mitsunobu reaction;
DOI:10.1021/ol026377m