Serinamide

Base Information

• Chemical Name: Serinamide
• CAS No.: 6791-49-7
• Molecular Formula: C3H8 N2 O2
• Molecular Weight: 104.109
• Hs Code.: 2924199090
• European Community (EC) Number: 229-862-8
• UNII: CIJ0MD19SE
• DSSTox Substance ID: DTXSID401317834
• Nikkaji Number: J298.118A
• ChEMBL ID: CHEMBL1229083
• Mol file: 6791-49-7.mol

Synonyms:Ser-NH2;serinamide;serine-NH2

Chemical Property of Serinamide

Chemical Property:

• Vapor Pressure: 8.9E-10mmHg at 25°C
• Boiling Point: 444.7°C at 760 mmHg
• Flash Point: 222.8°C
• PSA: 89.34000
• Density: 1.294g/cm³
• LogP: -0.80810
• XLogP3: -2.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 104.058577502
• Heavy Atom Count: 7
• Complexity: 73.3

Purity/Quality:

98.5% ^*data from raw suppliers

(S)-2-Amino-3-hydroxypropanamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C(=O)N)N)O
• Isomeric SMILES: C([C@@H](C(=O)N)N)O

Technology Process of Serinamide

There total 7 articles about Serinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride (5680-80-8) → L-serinamide (6791-49-7)

Guidance literature:

With ammonium hydroxide; at 20 ℃; for 5h;

Reference yield:

(S)-N-(tert-butoxycarbonyl)serine (3262-72-4) → L-serinamide (6791-49-7)

Guidance literature:

(S)-N-(tert-butoxycarbonyl)serine; With pyridine; di-tert-butyl dicarbonate; ammonium bicarbonate; In 1,4-dioxane; at 20 ℃; for 16h;

With trifluoroacetic acid; at 20 ℃; for 0.5h;

Reference yield:

(S)-serine methyl ester (2788-84-3) → L-serinamide (6791-49-7)

Guidance literature:

With ammonia;

DOI:10.1021/ja00871a030

upstream raw materials:

N-α-carbobenzoxy-L-serinamide

(S)-serine methyl ester

(S)-N-(tert-butoxycarbonyl)serine

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

Downstream raw materials:

Bz-Tyr-Ser-NH₂

L-serin

Refernces

• 1、 -. "Synthetic method for chiral alpha-aminoamide compounds". Paragraph 0056; 0057; 0058. . Retrieved 2018/01/11.
• 2、 -. "BIARYL HETEROCYCLIC AMINES, AMIDES, AND SULFUR-CONTAINING COMPOUNDS AND METHODS OF MAKING AND USING THE SAME". Page/Page column 64; 65. . Retrieved 2008/06/13.