Moexipril Diketopiperazine

Base Information

• Chemical Name: Moexipril Diketopiperazine
• CAS No.: 103733-51-3
• Molecular Formula: C27H32 N2 O6
• Molecular Weight: 480.561
• Hs Code.: 2933497050
• Mol file: 103733-51-3.mol

Synonyms:2H-Pyrazino[1,2-b]isoquinoline-2-aceticacid, 1,3,4,6,11,11a-hexahydro-8,9-dimethoxy-3-methyl-1,4-dioxo-a-(2-phenylethyl)-, ethyl ester,[3S-[2(R*),3a,11ab]]-; PD 114009

Chemical Property of Moexipril Diketopiperazine

Chemical Property:

• Melting Point: 74-77°C
• PSA: 85.38000
• LogP: 2.62810
• Storage Temp.: -20?C Freezer
• Solubility.: Chloroform, DMSO, Methanol

Purity/Quality:

97% ^*data from raw suppliers

MoexiprilDiketopiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Moexipril (M485350). The degradation kinetics of Moexipril produced by organic solvents. Moexipril USP Related Compound B. An impurity of Moexipril (M485350). The degradation kinetics of Moexipril produced by organic solvents.

Technology Process of Moexipril Diketopiperazine

There total 2 articles about Moexipril Diketopiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

moexipril hydrochloride (82586-52-5) → (S)-2-((3S,11aS)-8,9-Dimethoxy-3-methyl-1,4-dioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinolin-2-yl)-4-phenyl-butyric acid ethyl ester (103733-51-3)

Guidance literature:

With sodium acetate; In toluene; at 95 ℃; for 0.5h;

DOI:10.1021/jm00160a026

Reference yield:

<3S-<2>,3R*>-2-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>amino>-1-oxopropyl>-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid, phenylmethyl ester, hydrochloride (82586-51-4) → (S)-2-((3S,11aS)-8,9-Dimethoxy-3-methyl-1,4-dioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinolin-2-yl)-4-phenyl-butyric acid ethyl ester (103733-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / H₂ / Pd/C / tetrahydrofuran

2: 80 percent / AcONa / toluene / 0.5 h / 95 °C

With hydrogen; sodium acetate; palladium on activated charcoal; In tetrahydrofuran; toluene;

DOI:10.1021/jm00160a026

upstream raw materials:

moexipril hydrochloride

<3S-<2>,3R*>-2-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>amino>-1-oxopropyl>-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid, phenylmethyl ester, hydrochloride

Refernces