Technology Process of 2-Thiophenesulfonamide,
3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-
There total 5 articles about 2-Thiophenesulfonamide,
3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methoxybenzene; trifluoroacetic acid;
DOI:10.1021/jm049715t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hydroxide / dimethylsulfoxide / 2 h
1.2: 64 percent / dimethylsulfoxide / 1 h
2.1: 75 percent / aq. Na2CO3; Pd(PPh3)4 / ethanol; toluene / 0.08 h / 150 °C / microwave irradiation
3.1: anisole; TFA
With
potassium hydroxide; tetrakis(triphenylphosphine) palladium(0); sodium carbonate; methoxybenzene; trifluoroacetic acid;
In
ethanol; dimethyl sulfoxide; toluene;
2.1: Suzuki coupling;
DOI:10.1021/jm049715t
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium hydroxide / N,N-dimethyl-formamide / 16 h / Reflux
2: tetrakis(triphenylphosphine) palladium(0); sodium hydroxide / water; toluene / 3 h / Reflux
3: trifluoroacetic acid / neat (no solvent) / 16 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); trifluoroacetic acid; potassium hydroxide; sodium hydroxide;
In
water; N,N-dimethyl-formamide; toluene;
2: |Suzuki-Miyaura Coupling;
DOI:10.1002/open.201600091