4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE

Base Information

• Chemical Name: 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE
• CAS No.: 4862-94-6
• Molecular Formula: C8H12N2O3S
• Molecular Weight: 216.261
• Hs Code.: 2935009090
• Mol file: 4862-94-6.mol

Synonyms:amino-N-(2-hydroxyethyl)benzenesulfonamide;N-(2-hydroxyethyl)-4-aminobenzenesulfonamide;Sulfanilsaeure-(2-hydroxy-aethylamid);sulfanilic acid-(2-hydroxy-ethylamide);p-(2'-hydroxyethyl)-aminosulfonyl-aniline;2-Sulfanilamino-aethanol-(1);

Chemical Property of 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE

Chemical Property:

• Vapor Pressure: 1.06E-08mmHg at 25°C
• Melting Point: 97oC
• Boiling Point: 445oC at 760mmHg
• Flash Point: 222.9oC
• PSA: 100.80000
• Density: 1.383 g/cm3
• LogP: 1.59230

Purity/Quality:

98%min ^*data from raw suppliers

4-Amino-n-(2-hydroxyethyl)benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE

There total 5 articles about 4-AMINO-N-(2-HYDROXYETHYL)BENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

N-(2-hydroxyethyl)-4-nitrobenzenesulfonamide (18226-05-6) → N-(2-hydroxyethyl)-4-aminobenzene sulfonamide (4862-94-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;

Reference yield:

N-acetyl-sulfanilic acid-(2-hydroxy-ethylamide) (20535-76-6) → N-(2-hydroxyethyl)-4-aminobenzene sulfonamide (4862-94-6)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01872a020 DOI:10.1021/ja01878a022

Reference yield:

p-acetylaminobenzenesulfonyl chloride (121-60-8) → N-(2-hydroxyethyl)-4-aminobenzene sulfonamide (4862-94-6)

Guidance literature:

Multi-step reaction with 2 steps

2: aqueous hydrochloric acid

With hydrogenchloride;

DOI:10.1021/ja01872a020 DOI:10.1021/ja01878a022

upstream raw materials:

N-acetyl-sulfanilic acid-(2-hydroxy-ethylamide)

N-(2-hydroxyethyl)-4-nitrobenzenesulfonamide

4-Nitrobenzenesulfonyl chloride

p-acetylaminobenzenesulfonyl chloride

Downstream raw materials:

N-(N-acetyl-sulfanilyl)-sulfanilic acid-(2-hydroxy-ethylamide)

nitro-pyrimidine

N-sulfanilyl-sulfanilic acid-(2-hydroxy-ethylamide)

4-(6-amino-4-cyclohexylmethoxypyrimidin-2-ylamino)-N-(2-hydroxyethyl)benzenesulfonamide

Refernces

• 1、 Li, Cong,Deng, Xiaobing,Zhang, Weilin,Xie, Xiaowen,Conrad, Marcus,Liu, Ying,Angeli, José Pedro Friedmann,Lai, Luhua. "Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4". . p. 266 - 275. Retrieved 2019/01/15.
• 2、 -. "CHEMICAL COMPOUNDS-576". Page/Page column 56. . Retrieved 2008/12/06.