1-Cyclopentylpiperazine

Base Information

• Chemical Name: 1-Cyclopentylpiperazine
• CAS No.: 21043-40-3
• Molecular Formula: C9H18N2
• Molecular Weight: 154.255
• Hs Code.: 2933599090
• European Community (EC) Number: 671-072-4
• DSSTox Substance ID: DTXSID80355565
• Nikkaji Number: J1.642.603B
• Wikidata: Q72460519
• Mol file: 21043-40-3.mol

Synonyms:1-cyclopentylpiperazine;21043-40-3;1-Cyclopentyl-piperazine;n-cyclopentylpiperazine;MFCD00168029;4-Cyclopentylpiperazine;1-cyclopentyl piperazine;1-cyclo-pentyl piperazine;1-(cyclopentyl)-piperazine;SCHEMBL271868;DTXSID80355565;PVMCQBPJKPMOKM-UHFFFAOYSA-N;1-Cyclopentylpiperazine, AldrichCPR;STK488096;AKOS000147363;AB04250;LF-0540;BB 0221278;C2466;FT-0605823;EN300-30631;A815091;J-504559;F2168-0003;Z228588068

Chemical Property of 1-Cyclopentylpiperazine

Chemical Property:

• Appearance/Colour: little yellow or clear liquid
• Vapor Pressure: 0.0562mmHg at 25°C
• Refractive Index: 1.5000 to 1.5040
• Boiling Point: 233.3 °C at 760 mmHg
• PKA: 9.28±0.10(Predicted)
• Flash Point: 95.7 °C
• PSA: 15.27000
• Density: 0.989 g/cm³
• LogP: 1.10090
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Sparingly)
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 154.146998583
• Heavy Atom Count: 11
• Complexity: 113

Purity/Quality:

98.0% Min., ^*data from raw suppliers

1-?Cyclopentylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C1)N2CCNCC2
• Uses: 1-?Cyclopentylpiperazine is used in the synthesis of quinolines as a new class of imidazole-free H3 receptor antagonists. Also used to prepare a series of estrogen receptor modulators.

Technology Process of 1-Cyclopentylpiperazine

There total 1 articles about 1-Cyclopentylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-cyclopentylpiperazine (21043-40-3)

Guidance literature:

entspr. N-Phenylpiperazin, 1) NaNO2/HCl, 2) SO2, Erhitz.;

Reference yield: 86.0%

7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline (60771-18-8) + 1-cyclopentylpiperazine (21043-40-3) → 7-(benzyloxy)-2-chloro-4-(4-cyclopentylpiperazin-1-yl)-6-methoxyquinazoline

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield: 86.0%

2-Chloro-N-cyclohexylacetamide (23605-23-4) + 1-cyclopentylpiperazine (21043-40-3) → N-cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)acetamide (1259917-08-2)

Guidance literature:

With sodium carbonate; In ethanol; water; Reflux;

DOI:10.1080/00397911.2011.629357

Downstream raw materials:

C₂₄H₂₈FN₇S

5-(4-Cyclopentyl-piperazin-1-yl)-2-nitro-phenylamine

4-cyclopentylpiperazine-1-carboxylic acid 2-(3,4-di-methoxyphenyl)ethyl ester hydrochloride

4-Cyclopentyl-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester