2-Hydrazino-4-methylquinoline

Base Information

• Chemical Name: 2-Hydrazino-4-methylquinoline
• CAS No.: 21703-52-6
• Molecular Formula: C10H11N3
• Molecular Weight: 173.217
• Hs Code.: 2933990090
• European Community (EC) Number: 688-040-0
• DSSTox Substance ID: DTXSID30355919
• Nikkaji Number: J870.505D
• Wikidata: Q82135020
• Mol file: 21703-52-6.mol

Synonyms:2-hydrazino-4-methylquinoline;21703-52-6;2-hydrazinyl-4-methylquinoline;(4-Methyl-Quinolin-2-Yl)-Hydrazine;(4-methylquinolin-2-yl)hydrazine;MFCD00818533;Quinoline,2-hydrazinyl-4-methyl-;Enamine_004986;Oprea1_298738;Oprea1_351559;SCHEMBL1577669;DTXSID30355919;FLDYBLAUDDQRAB-UHFFFAOYSA-N;HMS1408C14;BBL029040;STK843524;AKOS000116762;SB67622;IDI1_007573;AS-61184;FT-0760599;EN300-03834;(4-methyl-quinolin-2-yl)-hydrazine, AldrichCPR;AF-399/25108037;F1030-0177

Chemical Property of 2-Hydrazino-4-methylquinoline

Chemical Property:

• Melting Point: 147-149 °C
• Boiling Point: 377 °C at 760 mmHg
• PKA: 5.54±0.20(Predicted)
• Flash Point: 181.8 °C
• PSA: 50.94000
• Density: 1.24g/cm³
• LogP: 2.60210
• Water Solubility.: Soluble in water.
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 173.095297364
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

NLT 98% ^*data from raw suppliers

(4-Methyl-quinolin-2-yl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC2=CC=CC=C12)NN
• Uses: 2-Hydrazino-4-methylquinoline is used as a pharmaceutical intermediate.

Technology Process of 2-Hydrazino-4-methylquinoline

There total 5 articles about 2-Hydrazino-4-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-methylquinoline (634-47-9) → 2-hydrazinyl-4-methylquinoline (21703-52-6)

Guidance literature:

With hydrazine hydrate; at 150 ℃;

Reference yield:

→ 2-hydrazinyl-4-methylquinoline (21703-52-6)

Guidance literature:

With hydrazine hydrate; at 200 ℃; im Rohr;

Reference yield:

→ 2-hydrazinyl-4-methylquinoline (21703-52-6) + N,N'-bis-(4-methyl-[2]quinolyl)-hydrazine (99925-93-6)

Guidance literature:

With hydrazine hydrate; at 200 ℃; im Rohr;

upstream raw materials:

2-chloro-4-methylquinoline

4-methylquinolin-2-ol

Downstream raw materials:

5-methyl-s-triazolo<4,3-a>quinoline

1-(4-chlorobenzylidene)-2-(4-methylquinolin-2-yl)hydrazine

N-(4-Methyl-quinolin-2-yl)-N'-[1-(3-nitro-phenyl)-meth-(E)-ylidene]-hydrazine

benzaldehyde-(4-methyl-[2]quinolylhydrazone)

Refernces

• 1、 -. "CONDENSED RING PYRIDINE COMPOUNDS AS SUBTYPE-SELECTIVE MODULATORS OF SPHINGOSINE-1-PHOSPHATE-2 (S1P2) RECEPTORS". Page/Page column 39. . Retrieved 2011/04/25.