Kanshone C

Base Information

• Chemical Name: Kanshone C
• CAS No.: 117634-64-7
• Molecular Formula: C₁₅H₂₀O₃
• Molecular Weight: 248.322
• Mol file: 117634-64-7.mol

Synonyms:

Chemical Property of Kanshone C

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Kanshone C

There total 2 articles about Kanshone C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

aristol-1(10)-en-9-one (114339-93-4) → nardosinone (23720-80-1) + kanshone C (117634-64-7) + 1(10)-Aristolen-9-on-2β-hydroperoxid (127843-30-5) + 1(10)-Aristolen-9-on-2α-hydroperoxid (127912-18-9)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); oxygen; at 80 ℃; for 8h;

DOI:10.1002/ardp.19903230308

Reference yield:

aristol-1(10)-en-9-one (114339-93-4) → nardosinone diol (20489-11-6) + Desoxo-Narchinol A (53859-06-6,127843-31-6) + nardosinone (23720-80-1) + kanshone C (117634-64-7)

Guidance literature:

With oxygen; In acetone; at 80 ℃; for 24h; Product distribution; different additives;

DOI:10.1002/ardp.19903230308

Reference yield:

kanshone C (117634-64-7) → Benzoic acid (1aS,4R,4aR,5S,8S,8aR)-5-isopropenyl-4,4a-dimethyl-2,3,4,4a,5,8-hexahydro-1aH-1-oxa-cyclopropa[d]naphthalen-8-yl ester

Guidance literature:

Multi-step reaction with 4 steps

1: NaBH₄ / methanol / 1 h / Ambient temperature

2: 1) N,N-dimethylformamide dimethyl acetal / 1) 120 deg C, 8 h, 2) 165 deg C, 45 min

3: 0.5M K₂CO₃ in MeOH / Ambient temperature

4: pyridine / Ambient temperature

With pyridine; methanol; sodium tetrahydroborate; potassium carbonate; N,N-dimethyl-formamide dimethyl acetal; In methanol;

DOI:10.1016/0031-9422(88)80680-0

upstream raw materials:

aristol-1⁽¹⁰⁾-en-9-one

Refernces