2-METHYL-PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 2-METHYL-PIPERIDINE HYDROCHLORIDE
• CAS No.: 5119-88-0
• Molecular Formula: C6H13 N . Cl H
• Molecular Weight: 135.637
• Hs Code.: 2933399090
• Mol file: 5119-88-0.mol

Synonyms:2-Pipecoline,hydrochloride (8CI); Piperidine, 2-methyl-, hydrochloride (9CI);2-Methylpiperidine hydrochloride; 2-Methylpiperidinium chloride; NSC 203093

Chemical Property of 2-METHYL-PIPERIDINE HYDROCHLORIDE

Chemical Property:

• PSA: 12.03000
• LogP: 2.27920
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-METHYLPIPERIDINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-PIPERIDINE HYDROCHLORIDE

There total 18 articles about 2-METHYL-PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-methyl-2,3,4,5-tetrahydro-pyridine (1462-92-6) → 2-methylpiperidine hydrochloride (5119-88-0,205526-61-0)

Guidance literature:

6-methyl-2,3,4,5-tetrahydro-pyridine; With methanol; sodium cyanoborohydride; zinc(II) chloride;

With hydrogenchloride; In water;

DOI:10.1002/adsc.200900302

Reference yield: 98.0%

1-[(S)-((R)-2-Methyl-piperidin-1-yl)-phenyl-methyl]-naphthalen-2-ol (667870-56-6) → (+)-(2R)-2-methylpiperidine hydrochloride (5119-88-0,205526-61-0)

Guidance literature:

With dichloromethane; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 48h; atmospheric pressure;

DOI:10.1021/jo0480444

Reference yield: 93.0%

(S)-4-isopropyl-3-(6-methylpyridin-2-yl)oxazolidin-2-one (737760-86-0) → (4S)-4-isopropyl-1,3-oxazolidin-2-one (17016-83-0) + (S)-2-methylpiperidine hydrochloride (5119-88-0,205526-61-0)

Guidance literature:

(S)-4-isopropyl-3-(6-methylpyridin-2-yl)oxazolidin-2-one; With hydrogen; acetic acid; 20% palladium hydroxide on carbon; at 50 ℃; for 22h; under 75007.5 Torr;

With hydrogenchloride; In methanol; water; Product distribution / selectivity;

upstream raw materials:

B(OC₂H₅)2(CH₂)4CH(N₃)CH₃

B(OH)2(CH₂)4CHBrCH₃

boron trichloride

6-methyl-2,3,4,5-tetrahydro-pyridine

Downstream raw materials:

3-(2'-methylpiperidino)-1-phenyl-propan-1-one hydrochloride

3-(2-methyl-piperidino)-1-(4-propoxy-phenyl)-propan-1-one

(R)-N,N'-(1,4-phenylenebis(methylene))bis(3-((R)-2-methylpiperidin-1-yl)propan-1-amine)

Refernces

• 1、 Wang, Xinyan,Dong, Yanmei,Sun, Jianwei,Xu, Xuenong,Li, Rui,Hu, Yuefei. "Nonracemic betti base as a new chiral auxiliary: Application to total syntheses of enantiopure (2S,6R)-dihydropinidine and (2S,6R)-isosolenopsins". . p. 1897 - 1900. Retrieved 2007/10/03.
• 2、 Andres, Jose M.,Herraiz-Sierra, Ignacio,Pedrosa, Rafael,Perez-Encabo, Alfonso. "A simple stereoselective synthesis of enantiopure 2-substituted pyrrolidines and piperidines from chiral (R)-phenylglycinol-derived bicyclic 1,3-oxazolidines". . p. 1719 - 1726. Retrieved 2007/10/03.