Technology Process of 2-Butenamide,
N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-,
(2E)-
There total 15 articles about 2-Butenamide,
N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-,
(2E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / propan-2-ol / 3.5 h / Heating
2: 89 percent / Fe; aq. NH4Cl / methanol / 4 h / Heating
3: N-methylmorpholine / tetrahydrofuran / 1 h
With
4-methyl-morpholine; iron; ammonium chloride;
In
tetrahydrofuran; methanol; isopropyl alcohol;
DOI:10.1021/jm020241c
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 65 percent / AcOH / 0.5 h / Heating
2: LiCl / dimethylformamide / 12 h / Heating
3: K2CO3 / dimethylformamide / 5 h / Heating
4: KMnO4; MgSO4 / H2O / 1.5 h / Heating
5: 71 percent / aq. H2SO4 / 1 h / 110 - 112 °C
6: 80 percent / toluene / 16 h / Heating
7: 76 percent / Dowtherm / 1.25 h / 256 °C
8: 87 percent / POCl3 / 2.5 h / Heating
9: 95 percent / propan-2-ol / 3.5 h / Heating
10: 89 percent / Fe; aq. NH4Cl / methanol / 4 h / Heating
11: N-methylmorpholine / tetrahydrofuran / 1 h
With
4-methyl-morpholine; potassium permanganate; diphenyl ether-biphenyl eutectic; sulfuric acid; iron; magnesium sulfate; potassium carbonate; ammonium chloride; acetic acid; lithium chloride; trichlorophosphate;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/jm020241c
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 80 percent / toluene / 16 h / Heating
2: 76 percent / Dowtherm / 1.25 h / 256 °C
3: 87 percent / POCl3 / 2.5 h / Heating
4: 95 percent / propan-2-ol / 3.5 h / Heating
5: 89 percent / Fe; aq. NH4Cl / methanol / 4 h / Heating
6: N-methylmorpholine / tetrahydrofuran / 1 h
With
4-methyl-morpholine; diphenyl ether-biphenyl eutectic; iron; ammonium chloride; trichlorophosphate;
In
tetrahydrofuran; methanol; isopropyl alcohol; toluene;
DOI:10.1021/jm020241c