N-(4-chlorophenyl)-2-methyl-propanamide

Base Information

• Chemical Name: N-(4-chlorophenyl)-2-methyl-propanamide
• CAS No.: 7160-05-6
• Molecular Formula: C10H12ClNO
• Molecular Weight: 197.664
• Mol file: 7160-05-6.mol

Synonyms:propanamide,n-(4-chlorophenyl)-2-methyl;isobutyric acid-(4-chloro-anilide);N-(4-chlorophenyl)-2-methyl-propanamide;p-chloroisobutyranilide;N-(4-chlorophenyl)-2,2-dimethylacetamide;4'-chloro-2-methylpropananilide;Isopropyl-N-4-chlorphenylcarbamat;Isobuttersaeure-(4-chlor-anilid);

Chemical Property of N-(4-chlorophenyl)-2-methyl-propanamide

Chemical Property:

• Vapor Pressure: 5.5E-05mmHg at 25°C
• Melting Point: 139 °C
• Boiling Point: 347.1°C at 760 mmHg
• PKA: 14.00±0.70(Predicted)
• Flash Point: 163.7°C
• PSA: 29.10000
• Density: 1.177g/cm³
• LogP: 3.00750

Purity/Quality:

99%min ^*data from raw suppliers

N-(4-CHLOROPHENYL)-2-METHYLPROPANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-chlorophenyl)-2-methyl-propanamide

There total 8 articles about N-(4-chlorophenyl)-2-methyl-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-chlorobenzonitrile (100-00-5) + isobutyric Acid (79-31-2) → N-(4-chlorophenyl)-2,2-dimethylacetamide (7160-05-6)

Guidance literature:

With sodium sulfite; for 16h; Reflux;

DOI:10.1246/cl.140454

Reference yield: 80.0%

2-Methylpropionic anhydride (97-72-3) + 4-chlorobenzonitrile (100-00-5) → N-(4-chlorophenyl)-2,2-dimethylacetamide (7160-05-6)

Guidance literature:

4-chlorobenzonitrile; With trichlorosilane; triethylamine; In acetonitrile; at 0 - 25 ℃; for 1.5h;

2-Methylpropionic anhydride; In acetonitrile; at 25 - 65 ℃; for 24h; chemoselective reaction;

DOI:10.1039/c9ra10758d

Reference yield: 60.0%

di(4-chlorophenyl)iodonium trifluoromethanesulfonate + Isobutyronitrile (78-82-0) → N-(4-chlorophenyl)-2,2-dimethylacetamide (7160-05-6)

Guidance literature:

With copper diacetate; In water; 1,2-dichloro-ethane; at 80 ℃; for 20h; Schlenk technique; Sealed tube;

upstream raw materials:

4-chloro-aniline

isobutyryl chloride

2-bromo-2-methyl-N-(p-chlorophenyl)propanamide

carbon dioxide

Downstream raw materials:

N-(2,4-dichlorophenyl)isobutyramide

2-bromo-2-methyl-N-(p-chlorophenyl)propanamide

Refernces

• 1、 Massolo, Elisabetta,Pirola, Margherita,Puglisi, Alessandra,Rossi, Sergio,Benaglia, Maurizio. "A one pot protocol to convert nitro-arenes into: N-aryl amides". . p. 4040 - 4044. Retrieved 2020/02/04.
• 2、 Mei, Chong,Lu, Wenjun. "Palladium(II)-Catalyzed Oxidative Homo- and Cross-Coupling of Aryl ortho -sp2 C-H Bonds of Anilides at Room Temperature". . p. 4812 - 4823. Retrieved 2018/04/26.