1,4-Dioxa-7-thiaspiro[4.4]nonane

Base Information

• Chemical Name: 1,4-Dioxa-7-thiaspiro[4.4]nonane
• CAS No.: 176-35-2
• Molecular Formula: C₆H₁₀O₂S
• Molecular Weight: 146.21
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID50381235
• Wikidata: Q82171938
• Mol file: 176-35-2.mol

Synonyms:1,4-dioxa-7-thiaspiro[4.4]nonane;176-35-2;SCHEMBL862365;POTASSIUMDIHYDROGENCITRATE;DTXSID50381235;MFCD00068021;AKOS006228237;CS-0448331;FT-0606895;3-deshydroxy-(5h)-4-methyl-3-oxo temazepam;W-206235

Chemical Property of 1,4-Dioxa-7-thiaspiro[4.4]nonane

Chemical Property:

• Vapor Pressure: 0.0468mmHg at 25°C
• Refractive Index: 1.546
• Boiling Point: 244.7 °C at 760 mmHg
• Flash Point: 101.8 °C
• PSA: 43.76000
• Density: 1.24 g/cm³
• LogP: 0.86640
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 146.04015073
• Heavy Atom Count: 9
• Complexity: 110

Purity/Quality:

98%min ^*data from raw suppliers

1,4-Dioxa-7-thiaspiro[4.4]nonane ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CSCC12OCCO2
• Uses: 1,4-Dioxa-7-thiaspiro[4.4]nonane is used in the synthesis of new dihydrothiophene sulfoxides.

Technology Process of 1,4-Dioxa-7-thiaspiro[4.4]nonane

There total 3 articles about 1,4-Dioxa-7-thiaspiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Tetrahydrothiophen-3-one (1003-04-9) + ethylene glycol (107-21-1) → 1,4-dioxa-6-thiaspiro<4.4>nonane (176-35-2)

Guidance literature:

toluene-4-sulfonic acid; In benzene; Heating;

DOI:10.1016/S0040-4020(01)89951-8

Reference yield:

1,4-dioxa-6-thiaspiro<4.4>nonane S-oxide (110431-53-3) → 1,4-dioxa-6-thiaspiro<4.4>nonane (176-35-2)

Guidance literature:

With dimethylsilicon dichloride; zinc; Ambient temperature;

Reference yield:

N-[1,4-Dioxa-7λ4-thia-spiro[4.4]non-(7Z)-ylidene]-4-methyl-benzenesulfonamide → 1,4-dioxa-6-thiaspiro<4.4>nonane (176-35-2)

Guidance literature:

With dimethylsilicon dichloride; zinc; Ambient temperature;

upstream raw materials:

Tetrahydrothiophen-3-one

ethylene glycol

1,4-dioxa-6-thiaspiro<4.4>nonane S-oxide

Refernces

• 1、 Nagasawa, Kazuo,Umezawa, Toshiyuki,Itoh, Kei-ichi. "FACILE REDUCTION OF SULFOXIDES AND SULFILIMINES TO SULFIDES BY USING METAL/CHLOROMETHYLSILANES". . p. 463. Retrieved 2007/10/02.