4-(DIETHOXYMETHYL)BENZALDEHYDE

Base Information

• Chemical Name: 4-(DIETHOXYMETHYL)BENZALDEHYDE
• CAS No.: 81172-89-6
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Hs Code.: 29124900
• Mol file: 81172-89-6.mol

Synonyms:1,4-Benzenedicarboxaldehydemono(diethyl acetal);4-(Diethoxymethyl)benzaldehyde;4-[Bis(ethoxy)methyl]benzaldehyde;Terephthalaldehyde mono(diethyl acetal);Terephthaldehyde diethyl monoacetal;Terephthaldehyde monodiethyl acetal;

Chemical Property of 4-(DIETHOXYMETHYL)BENZALDEHYDE

Chemical Property:

• Appearance/Colour: clear colorless to light yellow liquid
• Vapor Pressure: 0.00209mmHg at 25°C
• Refractive Index: n20/D 1.506(lit.)
• Boiling Point: 290.3 °C at 760 mmHg
• Flash Point: 120.2 °C
• PSA: 35.53000
• Density: 1.057 g/cm³
• LogP: 2.57070
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive
• Water Solubility.: soluble in alcohol, chlorinated solvents and toluene. Decomposes in water.

Purity/Quality:

98% ^*data from raw suppliers

Terephthalaldehyde Mono(diethyl Acetal) >97.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-(Diethoxymethyl)benzaldehyde was used in the synthesis of 4-(diethoxymethyl)benzyl alcohol.

Technology Process of 4-(DIETHOXYMETHYL)BENZALDEHYDE

There total 4 articles about 4-(DIETHOXYMETHYL)BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

terephthalaldehyde, (623-27-8) + orthoformic acid triethyl ester (122-51-0) → 4-(ethoxymethyl)benzaldehyde (95068-23-8) + terephthalaldehyde mono(diethylacetal) (81172-89-6)

Guidance literature:

With sulfuric acid; In ethanol; at 20 ℃; for 12h;

DOI:10.1021/ol0060329

Reference yield: 50.0%

terephthalaldehyde, (623-27-8) + orthoformic acid triethyl ester (122-51-0) → terephthalaldehyde mono(diethylacetal) (81172-89-6)

Guidance literature:

With ammonium chloride; In ethanol; at 0 - 20 ℃;

Reference yield:

4-(dibromomethyl)benzenecarbaldehyde + orthoformic acid triethyl ester (122-51-0) → 1-(dibromomethyl)-4-(diethoxymethyl)benzene + terephthalaldehyde mono(diethylacetal) (81172-89-6)

Guidance literature:

With zinc(II) chloride; In benzene; at 80 ℃; for 0.5h;

DOI:10.1134/S1070363217120052

upstream raw materials:

terephthalaldehyde,

orthoformic acid triethyl ester

ethanol

Downstream raw materials:

[2-(4-diethoxymethyl-phenyl)-1,1-difluoro-2-hydroxy-ethyl]-phosphonic acid diethyl ester

2-[1-(4-Diethoxymethyl-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid ethyl ester

4-[(1E)-2-(4-formylphenyl)ethenyl]benzonitrile

trans-4-cyano-4'-(N-(2-pyridyl)-amino)methylstilbene

Refernces

• 1、 Wang, Caolin,Xu, Shan,Peng, Liang,Zhang, Bingliang,Zhang, Hong,Hu, Yingying,Zheng, Pengwu,Zhu, Wufu. "Design, synthesis and biological evaluation of novel 4-anlinoquinazoline derivatives as EGFR inhibitors with the potential to inhibit the gefitinib-resistant nonsmall cell lung cancers". . p. 204 - 218. Retrieved 2019/01/03.
• 2、 Pan, Yu-Lu,Cai, Zhi-Bin,Bai, Li,Ma, Fei-Fei,Li, Sheng-Li,Tian, Yu-Peng. "Green synthesis and photophysical properties of novel 1H-imidazo[4,5-f][1,10]phenanthroline derivatives with blue/cyan two-photon excited fluorescence". . p. 2886 - 2893. Retrieved 2017/04/26.