Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-(triphenyl methyl)-1H-imidazol-4-yl]-, dimethyl ester

Base Information

• Chemical Name: Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-(triphenyl methyl)-1H-imidazol-4-yl]-, dimethyl ester
• CAS No.: 497160-01-7
• Molecular Formula: C₃₈H₃₈N₄O₆
• Molecular Weight: 646.743
• Mol file: 497160-01-7.mol

Synonyms:

Chemical Property of Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-(triphenyl methyl)-1H-imidazol-4-yl]-, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-(triphenyl methyl)-1H-imidazol-4-yl]-, dimethyl ester

There total 2 articles about Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-(triphenyl methyl)-1H-imidazol-4-yl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(1-trityl-1H-imidazol-4-yl)-malonic acid dimethyl ester (497160-00-6) + (5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester (304873-96-9) → 2-(6-tert-butoxycarbonylamino-pyridin-3-ylmethyl)-2-(1-trityl-1H-imidazol-4-yl)-malonic acid dimethyl ester (497160-01-7)

Guidance literature:

2-(1-trityl-1H-imidazol-4-yl)-malonic acid dimethyl ester; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 1.08333h;

(5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.5h;

Reference yield:

→ 2-(6-tert-butoxycarbonylamino-pyridin-3-ylmethyl)-2-(1-trityl-1H-imidazol-4-yl)-malonic acid dimethyl ester (497160-01-7)

Guidance literature:

upstream raw materials:

2-(1-trityl-1H-imidazol-4-yl)-malonic acid dimethyl ester

(5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester

Refernces

• 1、 -. "IMIDAZOLE DERIVATIVES USED AS TAFIA INHIBITORS". Page/Page column 62. . Retrieved 2010/02/14.