5-Bromo-2-ethoxypyridine

Base Information

• Chemical Name: 5-Bromo-2-ethoxypyridine
• CAS No.: 55849-30-4
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.051
• Hs Code.: 29333990
• DSSTox Substance ID: DTXSID50355774
• Nikkaji Number: J894.898D
• Wikidata: Q72455347
• Mol file: 55849-30-4.mol

Synonyms:5-Bromo-2-ethoxypyridine;55849-30-4;2-ethoxy-5-bromopyridine;Pyridine, 5-bromo-2-ethoxy-;3-BROMO-6-ETHOXYPYRIDINE;MFCD00234311;5-bromo-2-ethoxy-pyridine;5-bromo-ethoxy-pyridine;5-Bromo-2-Ethoxy Pyridine;SCHEMBL156935;5-bromo-2-(ethyloxy)pyridine;DTXSID50355774;5-Bromo-2-ethoxypyridine, 97%;AKOS005199250;AB05210;AC-5974;DS-0799;FS-1790;SY018882;A8062;AM20070041;B3673;CS-0014710;FT-0640343;EN300-225185;AC-907/25004667;J-516916

Chemical Property of 5-Bromo-2-ethoxypyridine

Chemical Property:

• Appearance/Colour: Light yellow crystal
• Vapor Pressure: 0.207mmHg at 25°C
• Melting Point: 32-36 °C(lit.)
• Refractive Index: 1.534
• Boiling Point: 216.3 °C at 760 mmHg
• PKA: 1.68±0.22(Predicted)
• Flash Point: 84.6 °C
• PSA: 22.12000
• Density: 1.449 g/cm³
• LogP: 2.24280
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.97893
• Heavy Atom Count: 10
• Complexity: 99.6

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-ethoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41
• Safety Statements: 26-36/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC1=NC=C(C=C1)Br

Technology Process of 5-Bromo-2-ethoxypyridine

There total 10 articles about 5-Bromo-2-ethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,5-dibromopyridine (624-28-2) + ethanol (64-17-5) → 5-bromo-2-ethoxypyridine (55849-30-4)

Guidance literature:

With sodium; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

Reference yield: 95.0%

→ 5-bromo-2-ethoxypyridine (55849-30-4)

Guidance literature:

With sodium hydroxide;

Reference yield: 88.0%

2,5-dibromopyridine (624-28-2) + sodium ethanolate (141-52-6) → 5-bromo-2-ethoxypyridine (55849-30-4)

Guidance literature:

In ethanol; for 18h; Heating / reflux;

upstream raw materials:

2,5-dibromopyridine

ethanol

2-ethoxypyridine

5-bromo2-nitropyridine

Downstream raw materials:

2-ethoxy-5-pyridineboronic acid

3-bromo-6-ethoxy-4-pyridylboronic acid

6-ethoxy-3-pyridinecarboxaldehyde

2-(ethyloxy)-5-(4-{[1-(4-{[(5-methylpyridin-2-yl)methyl]oxy}phenyl)hydrazino]methyl}phenyl)pyridine

Refernces

• 1、 -. "PYRROLIDINONE DERIVATIVES AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS". Page/Page column 45; 67. . Retrieved 2014/05/07.
• 2、 Anderson, Erin D.,Boger, Dale L.. "Inverse electron demand diels-alder reactions of 1,2,3-triazines: Pronounced substituent effects on reactivity and cycloaddition scope". supporting information; experimental part. p. 12285 - 12292. Retrieved 2011/09/16.