2,3,5-trihydroxybenzoic acid

Base Information

• Chemical Name: 2,3,5-trihydroxybenzoic acid
• CAS No.: 33580-60-8
• Molecular Formula: C7H6O5
• Molecular Weight: 170.122
• Mol file: 33580-60-8.mol

Synonyms:

Chemical Property of 2,3,5-trihydroxybenzoic acid

Chemical Property:

• Vapor Pressure: 4.93E-08mmHg at 25°C
• Boiling Point: 426.5°C at 760 mmHg
• Flash Point: 225.9°C
• Density: 1.749g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,5-trihydroxybenzoic acid

There total 5 articles about 2,3,5-trihydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.5%

3,5-Dihydroxybenzoic acid (99-10-5) → 2,3,5-trihydroxybenzoic acid (33580-60-8)

Guidance literature:

With sodium hydroxide; ammonium peroxydisulfate; In water; at 20 ℃; Cooling;

Reference yield:

salicylic acid (69-72-7,25496-36-0,8052-31-1) → 2,5-dihydroxybenzoic acid. (490-79-9) + 2,3,5-trihydroxybenzoic acid (33580-60-8)

Guidance literature:

With sodium hydroxide; ammonium peroxydisulfate;

DOI:10.1021/jo50005a018

Reference yield:

salicylic acid (69-72-7,25496-36-0,8052-31-1) → 2,5-dihydroxybenzoic acid. (490-79-9) + 2,3,5-trihydroxybenzoic acid (33580-60-8)

Guidance literature:

DOI:10.1021/jo50005a018

upstream raw materials:

3,5-Dihydroxybenzoic acid

2,3,5-trimethoxybenzoic acid

salicylic acid

1-bromo-2,3,5-trimethoxybenzene

Downstream raw materials:

3,5-dimethoxysalicylic acid

2,3,5-triacetoxy-benzoyl chloride

2,3,5‐trihydroxybenzaldehyde

1-oxo-1-(2,3,5-tribenzyloxyphenyl)propan-2-ylphosphonic bis(dimethylamide)

Refernces

• 1、 Montersino, Stefania,Van Berkel, Willem J.H.. "Functional annotation and characterization of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1". experimental part. p. 433 - 442. Retrieved 2012/07/14.