Glu-Tyr

Base Information

• Chemical Name: Glu-Tyr
• CAS No.: 3422-39-7
• Molecular Formula: C14H18N2O6
• Molecular Weight: 310.307
• DSSTox Substance ID: DTXSID90326069
• Nikkaji Number: J3.254.623D
• Wikidata: Q27140594
• Metabolomics Workbench ID: 78794
• Mol file: 3422-39-7.mol

Synonyms:H-Glu-Tyr-OH;Glu-Tyr;L-Glutamyl-L-Tyrosine;glutamyltyrosine;3422-39-7;EY dipeptide;glutamyl-tyrosine;alpha-Glu-Tyr;E-Y Dipeptide;alpha-L-Glu-L-Tyr;L-Glu-L-Tyr;L-Glutamyl-L-Tyrosin;Glutamate Tyrosine dipeptide;Glutamate-Tyrosine dipeptide;L-alpha-glutamyl-L-tyrosine;SCHEMBL159463;CHEBI:73513;DTXSID90326069;EY;MFCD00063199;L-Tyrosine, L-.alpha.-glutamyl-, monomer;Q27140594;Melanin synthesized from Glu-Tyr substrate catalyzed by tyrosinase for 40 hrs;(4S)-4-amino-5-[[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-5-oxo-pentanoic acid;E-Y

Chemical Property of Glu-Tyr

Chemical Property:

• Vapor Pressure: 4.15E-20mmHg at 25°C
• Refractive Index: 1.606
• Boiling Point: 692.1 °C at 760 mmHg
• Flash Point: 372.3 °C
• PSA: 149.95000
• Density: 1.414 g/cm³
• LogP: 0.78740
• Storage Temp.: -15°C
• XLogP3: -3.8
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 8
• Exact Mass: 310.11648630
• Heavy Atom Count: 22
• Complexity: 406

Purity/Quality:

99%+, ^*data from raw suppliers

H-Glu-Tyr-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(C(=O)O)NC(=O)C(CCC(=O)O)N)O
• Isomeric SMILES: C1=CC(=CC=C1C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)N)O
• Uses: H-Glu-Tyr-OH is an Angiotensin-?converting enzyme (ACE) inhibitory peptide derived from food proteins widely reported for hypertension treatment.

Technology Process of Glu-Tyr

There total 12 articles about Glu-Tyr which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(O-benzyl-N-benzyloxycarbonyl-L-α-glutamyl)-L-tyrosine benzyl ester (34312-72-6) → H-α-Glu-Tyr-OH (3422-39-7)

Guidance literature:

With methanol; palladium; acetic acid; Hydrogenolyse;

Reference yield:

N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid (5680-86-4) → H-α-Glu-Tyr-OH (3422-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorocarbonic acid isobutyl ester; triethylamine; toluene / anschliessend Behandeln mit L-Tyrosin-benzylester-toluol-4-sulfonat in CHCl₃

2: palladium; acetic acid; aqueous methanol / Hydrogenolyse

With methanol; palladium; acetic acid; triethylamine; toluene; isobutyl chloroformate;

Reference yield:

tyrosine benzyl ester hydrochloride (15035-17-3) → H-α-Glu-Tyr-OH (3422-39-7)

Guidance literature:

Multi-step reaction with 2 steps

2: H₂ / Pd

With hydrogen; palladium;

upstream raw materials:

N-(O-benzyl-N-benzyloxycarbonyl-L-α-glutamyl)-L-tyrosine benzyl ester

N-(N-phenylsulfanylcarbonyl-L-α-glutamyl)-L-tyrosine ethyl ester

N-benzyloxycarbonyl-L-glutamyl-L-tyrosine

N-(N-benzyloxycarbonyl-L-α-glutamyl)-L-tyrosine ethyl ester

Refernces