2-(Dimethoxymethyl)-2,5-dihydro-2,5-dimethoxyfuran

Base Information

• Chemical Name: 2-(Dimethoxymethyl)-2,5-dihydro-2,5-dimethoxyfuran
• CAS No.: 59906-91-1
• Molecular Formula: C9H16 O5
• Molecular Weight: 204.223
• European Community (EC) Number: 261-980-5
• DSSTox Substance ID: DTXSID50975330
• Nikkaji Number: J298.740F
• Mol file: 59906-91-1.mol

Synonyms:59906-91-1;2,5-DIHYDRO-2,5-DIMETHOXY-2-DIMETHOXYMETHYLFURAN;2-(Dimethoxymethyl)-2,5-dihydro-2,5-dimethoxyfuran;5-(dimethoxymethyl)-2,5-dimethoxy-2H-furan;2-(dimethoxymethyl)-2,5-dimethoxy-2,5-dihydrofuran;EINECS 261-980-5;promethazineteoclate;DTXSID50975330;2,5-Dimethoxy-2,5-dihydro-2-furaldehyde;FT-0736967;2,5-dimethoxy-2-dimethoxymethyl-2,5-dihydro-furan

Chemical Property of 2-(Dimethoxymethyl)-2,5-dihydro-2,5-dimethoxyfuran

Chemical Property:

• Vapor Pressure: 0.0276mmHg at 25°C
• Boiling Point: 254.4°C at 760 mmHg
• Flash Point: 95.3°C
• PSA: 46.15000
• Density: 1.1g/cm³
• LogP: 0.50690
• XLogP3: 0
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 204.09977361
• Heavy Atom Count: 14
• Complexity: 201

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dihydro-2,5-dimethoxy-2-dimethoxymethylfuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1C=CC(O1)(C(OC)OC)OC

Technology Process of 2-(Dimethoxymethyl)-2,5-dihydro-2,5-dimethoxyfuran

There total 11 articles about 2-(Dimethoxymethyl)-2,5-dihydro-2,5-dimethoxyfuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.2%

methanol (67-56-1) + 2-(furan-2-yl)-1,3-dioxolane (1708-41-4) → 2,5-dihydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal (59906-91-1)

Guidance literature:

With ammonium bromide; at -15 ℃; for 3h; electrolysis (current of 2.7 - 3.0 A at 12 - 14 V);

DOI:10.1007/BF00762049

Reference yield: 13.0%

methanol (67-56-1) + 2-furaldehyde dimethyl acetal (1453-62-9) → cis-2,5-dihydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal (38588-78-2,38588-79-3,59906-91-1) + trans-2,5-dihydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal (38588-78-2,38588-79-3,59906-91-1)

Guidance literature:

With N-Bromosuccinimide; sodium acetate; In diethyl ether; at 5 ℃; for 0.5h;

DOI:10.1016/0008-6215(93)84254-4

Reference yield: 13.0%

methanol (67-56-1) + 2-furaldehyde dimethyl acetal (1453-62-9) → cis-2,5-dihydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal (38588-78-2,38588-79-3,59906-91-1) + trans-2,5-dihydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal (38588-78-2,38588-79-3,59906-91-1)

Guidance literature:

With N-Bromosuccinimide; sodium acetate; In diethyl ether; at 5 ℃; for 0.5h;

DOI:10.1016/0008-6215(93)84254-4

upstream raw materials:

furfural

methanol

2-furaldehyde dimethyl acetal

2-(furan-2-yl)-1,3-dioxolane

Downstream raw materials:

8-Hydroxy-dihydro-thiazolo<3.2-a>piperidinium-3-carboxylat

N-phenylpyrrole-2-carbaldehyde

cis-tetrahydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal

trans-tetrahydro-2,5-dimethoxy-2-furaldehyde dimethyl acetal

Refernces

• 1、 Peresada, V. P.,Ostrovskaya, R. U.,Likhosherstov, A. M.,Rodionov, A. P.,Rozenberg, S. G.,Skoldinov, A. P.. "SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF SOME 2,5-DIALKOXY-2-(DIALKOXYMETHYL)TETRAHYDROFURANS". . p. 341 - 346. Retrieved 2007/10/02.