6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol

Base Information

• Chemical Name: 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol
• CAS No.: 7400-06-8
• Molecular Formula: C10H17N3O3
• Molecular Weight: 227.263
• Hs Code.: 2933599090
• Mol file: 7400-06-8.mol

Synonyms:6-amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol;4-Amino-5-<2,2-diaethoxy-aethyl>-6<1H>-pyrimidinon;4-Amino-6-hydroxy-5-(2,2-diaethoxy-aethyl)-pyrimidin;4-Amino-5-<2,2-diaethoxy-aethyl>-6-hydroxy-pyrimidin;6-AMINO-5(2,2-DIETHOXYETHYL)-4-HYDROXY PYRIMIDINE;6-amino-5-(2,2-diethoxy-ethyl)-3H-pyrimidin-4-one;6-Amino-4-hydroxy-5-(2,2-diaethoxy-aethyl)-pyrimidin;

Chemical Property of 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol

Chemical Property:

• Vapor Pressure: 0.000116mmHg at 25°C
• Melting Point: 193-196°C
• Boiling Point: 336°C at 760 mmHg
• PKA: 10.08±0.50(Predicted)
• Flash Point: 157°C
• PSA: 90.49000
• Density: 1.26g/cm³
• LogP: 1.28720
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Amino-5(2,2-diethoxyethyl)-4-hydroxyPyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol

There total 11 articles about 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-amino-5-(2,2-diethoxy)-2-mercaptopyrimidine-4-ol (7400-05-7) → 6-amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol (7400-06-8)

Guidance literature:

With ammonia; nickel; In water; at 90 ℃;

Reference yield: 85.0%

6-amino-5-(2,2-diethoxyethyl)-2-mercaptopyrimidin-4-ol ? → 6-amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol (7400-06-8)

Guidance literature:

With ammonia; In water; at 90 ℃;

DOI:10.1016/j.bmc.2012.08.050

Reference yield: 85.0%

ethyl 2-cyano-4,4-diethoxybutyrate (52133-67-2) + formamidine acetic acid (3473-63-0) → 6-amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol (7400-06-8)

Guidance literature:

With sodium ethanolate; In ethanol; at 76 - 78 ℃; for 5h; Inert atmosphere;

DOI:10.1002/ardp.201800040

upstream raw materials:

6-amino-5-(2,2-diethoxy)-2-mercaptopyrimidine-4-ol

ethyl 2-cyano-4,4-diethoxybutyrate

formamidine acetic acid

Bromoacetaldehyde diethyl acetal

Downstream raw materials:

7-deazahypoxanthine

Allopurinol

4-chloro-1H-pyrrolo[2,3-d]pyrimidine

4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

Refernces

• 1、 Patil, Yogesh,Shingare, Ramesh,Choudhari, Amit,Borkute, Rachana,Sarkar, Dhiman,Madje, Balaji R.. "Synthesis and biological evaluation of some new tricyclic pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine derivatives as potential antitubercular agents". . . Retrieved 2018/08/07.
• 2、 -. "PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS". Page/Page column 100-101. . Retrieved 2010/08/07.