N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide
• CAS No.: 1146-43-6
• Molecular Formula: C13H13 N O3 S
• Molecular Weight: 263.317
• NSC Number: 528444
• UNII: F2BKH6ZHT8
• DSSTox Substance ID: DTXSID20150793
• Nikkaji Number: J203.404B
• Wikidata: Q83016994
• ChEMBL ID: CHEMBL3360255
• Mol file: 1146-43-6.mol

Synonyms:N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide;1146-43-6;N-(4-Hydroxyphenyl)-p-toluenesulphonamide;N-(4-hydroxyphenyl)-4-methylbenzene-1-sulfonamide;F2BKH6ZHT8;N-(4-hydroxyphenyl)-p-toluenesulfonamide;CHEMBL3360255;Benzenesulfonamide, N-(4-hydroxyphenyl)-4-methyl-;EINECS 214-550-6;NSC-528444;N-(4-Hydroxy-phenyl)-4-methyl-benzenesulfonamide;C13H13NO3S;NSC528444;4-(Tosylamino)phenol;UNII-F2BKH6ZHT8;Oprea1_027229;Oprea1_132538;SCHEMBL930602;DTXSID20150793;BAA14643;BDBM50027958;MFCD00183142;STL428859;AKOS001036467;NSC 528444;CS-0199280;EN300-16025;E85556;N-(4-Hydroxyphenyl)-4-methylbenzenesulphonamide;AG-668/02826017;SR-01000481295;Benzenesulphonamide, N-(4-hydroxyphenyl)-4-methyl-;SR-01000481295-1;Z45652946

Chemical Property of N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.34E-08mmHg at 25°C
• Boiling Point: 446.9°C at 760 mmHg
• Flash Point: 224°C
• Density: 1.362g/cm³
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 263.06161445
• Heavy Atom Count: 18
• Complexity: 347

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)O

Technology Process of N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide

There total 19 articles about N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(4-(benzyloxy)phenyl)-N-(2,3-dimethylbut-2-enyl)-4-methylbenzenesulfonamide → N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide (1146-43-6)

Guidance literature:

With boron trichloride; In dichloromethane; at 20 ℃;

DOI:10.1055/s-0034-1379428

Reference yield: 93.0%

4-amino-phenol (123-30-8) + N,N-dimethyl-1-(p-tolylsulfonyl)pyridin-1-ium-4-amine chloride (72973-25-2) → N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide (1146-43-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.0833333h; chemoselective reaction; Green chemistry;

DOI:10.1016/j.tetlet.2016.09.010

Reference yield: 92.0%

4-amino-phenol (123-30-8) + p-toluenesulfonyl chloride (98-59-9) → N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide (1146-43-6)

Guidance literature:

With pyridine; at 20 ℃; for 6h;

DOI:10.1021/ol047498k

upstream raw materials:

ethanol

4-amino-phenol

p-toluenesulfonyl chloride

4-methyl-N-(4-oxocyclohexa-2,5-dien-1-ylidene)benzenesulfonamide

Downstream raw materials:

4-methyl-N-(4-oxocyclohexa-2,5-dien-1-ylidene)benzenesulfonamide

4-{[(4-methylphenyl)sulfonyl]amino}phenyl 4-methylbenzenesulfonate

toluene-4-sulfonic acid-[4-(2,4-dinitro-phenoxy)-anilide]

tetrabromobenzoquinone

Refernces

• 1、 Altman, Ryan A.,Douglas, Justin T.,Orsi, Douglas L.,Sorrentino, Jacob P.. "Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes". . p. 10451 - 10465. Retrieved 2020.
• 2、 Jiang, Jun,Zeng, Sheng,Chen, De,Cheng, Chaozhihui,Deng, Wei,Xiang, Jiannan. "Synthesis of: N -arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium". supporting information. p. 5016 - 5020. Retrieved 2018/07/25.