Technology Process of 3,6-dimethyl-9H-fluorene
There total 1 articles about 3,6-dimethyl-9H-fluorene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Mg / diethyl ether / 1 h / 20 °C
1.2: 4.88 g / diethyl ether / 5 h / -78 - 0 °C
2.1: polyphosphoric acid; phosphoric acid / 1 h / 75 - 80 °C
3.1: KOH / propan-2-ol / 1.25 h / Heating
With
potassium hydroxide; PPA; phosphoric acid; magnesium;
In
diethyl ether; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid; bromine / chloroform / 4 h / 5 - 20 °C / Inert atmosphere
2.1: pyridine; N-benzyl-trimethylammonium hydroxide / 24 h / 40 - 60 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - -75 °C / Inert atmosphere
3.2: 2 h / -75 - 20 °C
With
pyridine; n-butyllithium; bromine; N-benzyl-trimethylammonium hydroxide; trifluoroacetic acid;
In
tetrahydrofuran; hexane; chloroform;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid; bromine / chloroform / 4 h / 5 - 20 °C / Inert atmosphere
2.1: pyridine; N-benzyl-trimethylammonium hydroxide / 24 h / 40 - 60 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - -75 °C / Inert atmosphere
3.2: 2 h / -75 - 20 °C
4.1: trifluoroacetic acid; triethylsilane / hexane / 3 h / 70 °C / Inert atmosphere
With
pyridine; triethylsilane; n-butyllithium; bromine; N-benzyl-trimethylammonium hydroxide; trifluoroacetic acid;
In
tetrahydrofuran; hexane; chloroform;