alpha-((4-Phenyl-1-piperazinyl)methyl)-2-quinolinemethanol

Base Information

• Chemical Name: alpha-((4-Phenyl-1-piperazinyl)methyl)-2-quinolinemethanol
• CAS No.: 126921-32-2
• Molecular Formula: C₂₁H₂₃N₃O
• Molecular Weight: 333.433
• DSSTox Substance ID: DTXSID70925736
• Mol file: 126921-32-2.mol

Synonyms:BRN 4510883;alpha-((4-Phenyl-1-piperazinyl)methyl)-2-quinolinemethanol;126921-32-2;2-Quinolinemethanol, alpha-((4-phenyl-1-piperazinyl)methyl)-;DTXSID70925736;LS-142021;2-(4-Phenylpiperazin-1-yl)-1-(quinolin-2-yl)ethan-1-ol

Chemical Property of alpha-((4-Phenyl-1-piperazinyl)methyl)-2-quinolinemethanol

Chemical Property:

• Vapor Pressure: 6.46E-12mmHg at 25°C
• Boiling Point: 526.6°Cat760mmHg
• Flash Point: 272.3°C
• Density: 1.205g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 333.184112366
• Heavy Atom Count: 25
• Complexity: 404

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CC(C2=NC3=CC=CC=C3C=C2)O)C4=CC=CC=C4

Technology Process of alpha-((4-Phenyl-1-piperazinyl)methyl)-2-quinolinemethanol

There total 5 articles about alpha-((4-Phenyl-1-piperazinyl)methyl)-2-quinolinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-Phenyl-piperazin-1-yl)-1-quinolin-2-yl-ethanone → 2-(4-Phenyl-piperazin-1-yl)-1-quinolin-2-yl-ethanol (126921-32-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 4h; Heating;

Reference yield:

quinolin-2-ylcarbonyl chloride (50342-01-3) → 2-(4-Phenyl-piperazin-1-yl)-1-quinolin-2-yl-ethanol (126921-32-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / diethyl ether / 12 h / 0 °C

2: 80 percent / 48percent hydrobromic acid / diethyl ether / 0.5 h / 0 °C

3: benzene / 0 - 5 °C

4: LiAlH₄ / tetrahydrofuran; diethyl ether / 4 h / Heating

With lithium aluminium tetrahydride; hydrogen bromide; In tetrahydrofuran; diethyl ether; benzene;

Reference yield:

quinoline-2-carboxylic acid (93-10-7,1199266-78-8) → 2-(4-Phenyl-piperazin-1-yl)-1-quinolin-2-yl-ethanol (126921-32-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / SOCl₂

2: 100 percent / diethyl ether / 12 h / 0 °C

3: 80 percent / 48percent hydrobromic acid / diethyl ether / 0.5 h / 0 °C

4: benzene / 0 - 5 °C

5: LiAlH₄ / tetrahydrofuran; diethyl ether / 4 h / Heating

With lithium aluminium tetrahydride; thionyl chloride; hydrogen bromide; In tetrahydrofuran; diethyl ether; benzene;

upstream raw materials:

quinolin-2-ylcarbonyl chloride

quinoline-2-carboxylic acid

2-bromo-1-(quinolin-2-yl)ethan-1-one

2-quinolyl diazomethyl ketone

Refernces