4,4-DIMETHYL ITACONIC ACID

Base Information

• Chemical Name: 4,4-DIMETHYL ITACONIC ACID
• CAS No.: 584-27-0
• Molecular Formula: C7H10 O4
• Molecular Weight: 158.154
• Mol file: 584-27-0.mol

Synonyms:Butanedioicacid, (1-methylethylidene)- (9CI); Succinic acid, isopropylidene- (7CI,8CI);Teraconic acid (6CI); Isopropylidenesuccinic acid

Chemical Property of 4,4-DIMETHYL ITACONIC ACID

Chemical Property:

• Melting Point: 160.5°C
• Refractive Index: 1.4610 (estimate)
• Boiling Point: 203.22°C (rough estimate)
• PSA: 74.60000
• Density: 1.1229 (rough estimate)
• LogP: 0.88210

Purity/Quality:

99.90% ^*data from raw suppliers

4,4-DIMETHYL ITACONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4-DIMETHYL ITACONIC ACID

There total 38 articles about 4,4-DIMETHYL ITACONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl bromide (74-96-4) + succinic acid diethyl ester (123-25-1) → 2-isopropylidenesuccinic acid (584-27-0)

Guidance literature:

In ethanol; potassium tert-butylate; water; N,N-dimethyl-formamide; acetone;

Reference yield: 82.0%

succinic acid diethyl ester (123-25-1) → 2-isopropylidenesuccinic acid (584-27-0)

Guidance literature:

succinic acid diethyl ester; With potassium; acetone; tert-butyl alcohol; for 0.333333h; Reflux;

With sodium hydroxide; In water; Reflux;

DOI:10.1016/j.bmc.2009.01.050

Reference yield: 78.0%

3-(methoxycarbonyl)-4-methylpent-3-enoic acid (130165-83-2) → 2-isopropylidenesuccinic acid (584-27-0)

Guidance literature:

3-(methoxycarbonyl)-4-methylpent-3-enoic acid; With ethanol; potassium hydroxide; for 8h; Reflux;

With hydrogenchloride; In ethanol; water; at 0 ℃;

upstream raw materials:

terebic acid

isopropenyl-succinic acid

diethyl isopropylidenesuccinate

3-methyl-but-3-ene-1,1,2-tricarboxylic acid

Downstream raw materials:

dihydro-5,5-dimethyl-2(3H)-furanone

Oxalacetic acid

oxalic acid

acetic acid

Refernces

• 1、 Wang, Xiaokui,Lin, Jian,Chen, Yao,Zhong, Wu,Zhao, Guoming,Liu, Hongying,Li, Site,Wang, Lili,Li, Song. "Novel fatty acid synthase (FAS) inhibitors: Design, synthesis, biological evaluation, and molecular docking studies". experimental part. p. 1898 - 1904. Retrieved 2009/05/26.
• 2、 Ballini, Roberto,Bosica, Giovanna,Palmieri, Alessandro,Petrini, Marino,Pierantozzi, Claudio. "Conjugate addition of nitroalkanes to dimethyl maleate. Regioselective formation of both monoesters of 2-alkylsuccinic acids". . p. 7283 - 7289. Retrieved 2007/10/03.